Dsyfunction In Blood Vessel Walls Could Be Risk Factor For Alzheimer's As Well As Heart Disease

This study showed that inhibition of endiothelial nitric oxide synthase in blood vessel walls triggered a cascade leading to increased production of APP and higher levels of BACE1. Cerebral circulation problems could be at the root of Alzheimer's disease. Indeed, carotid artery atherosclerosis is observed in a large number of Alzheimer's patients (Refs ) as is atherosclerosis of the circle of Willis and other cerebral arteries  Refs : 

Thus far, Beta amyloid -based therapies have not been successful, but these atherosclerotic problems are detectable and to some extent treatable.