Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.

Homocysteine levels are a risk factor in Alzheimer's disease, (see database) and this study showed that manipulation of homocysteine levels in APP transgenic mice modified beta-amyloid deposition and also has effects on brain cholesterol levels. Homocysteine and methionine metabolism regulate B vitamin synthesis . B vitamins may have beneficial effects in Alzheimer's disease and ageing (see posts).


See also Kegg pathways for homocysteine, methionine and Vitamin B6 metabolism