Brain-specific phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an NMDA receptor co-agonist

Activated NMDARImage via Wikipedia
D-3-phosphoglycerate dehydrogenase is the enzyme responsible for the synthesis of L-serine , which is then converted to the glycine site NMDA agonist. D-serine, by serine racemase
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