Non-coding Repeats Cause Peptide Clumps | The Scientist Magazine®

A repetitive DNA sequence that was not believed to encode proteins is, in fact, the source of insoluble peptide chains that aggregate in the brain cells of patients displaying certain types of neurodegeneration,(FTLD-ALS spectrum disorders) according to a study published today (February 7) in Science. These aggregates occur in a wide range of neurodegenerative disorders, so determining their identity is an important first step towards understanding how they might contribute to various pathologies.

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