"Diet" soft drink consumption is associated with increased waist circumference in humans, and aspartame raised fasting glucose (blood sugar) in diabetes-prone mice.
The toxic effects of aspartame have been known for decades following John Olney's pioneering work with excitotoxins in 1969:
In 1981, this paper , by Takasaki et al showed that feeding aspartame to thirsty young mice produced ledions in the arcuate nucleus, the hypothalamic region that controls appetite.
Other work has also linked aspartame to weight gain Yang 2010 and others
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