Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia.

Polymorphisms in IL1B, TLR9, TNF alpha , CD95, STAT3 and TNFR determine the manifestation of the basic defect in  cystic fibrosis despite the fact that this is a monogenic condition caused by CFTR mutations.

Cystic fibrosis CFTR interactome