Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model.

In XMRV envelope vaccinated mice XMRV antibodies peak transiently and then rapidly disappear. This perhaps explains the differing prevalences reported for XMRV in prostate cancer and chronic fatigue syndrome studies. The low level of immunogenicity could be a characteristic of XMRV infection in humans. Lack of antibodies does not therefore necessarily preclude the presence of an earlier infection.