Mitochondria, oligodendrocytes and inflammation in bipolar disorder: Evidence from transcriptome studies points to intriguing parallels with multiple

Oligodendrocyte cell loss is a feature of both Bipolar disorder and schizophrenia, and of course , multiple sclerosis, in fact all demyelinating conditions, and all degenerative disorders. For Bipolar disorder or schizophrenia , this aspect does not seem to be the current focus of the effort to find new drugs. The beneficial effects of  the glutathione precursor N-acetyl cysteine in schizophrenia Berk et al, 2008 and for depressive symptoms in bipolar disorder Burk et al 2008 merits attention, as glutathione protects oligodendrocytes Review.

Risk factors:Bipolar disorder : Multiple sclerosis  Schizophrenia
Kegg pathways Schizophrenia