Viral (see
BLASTS) and
these papers from Kanduc's lab, and bacterial proteins (
Trost et al, 2010) show extensive homology (pentapeptides or more) with all human proteins: Because of this , they are able to mimic or block the actions of their human counterparts and compete with their binding partners in
interactomes.
DISC1 is no exception and an example of viruses that bind to DISC1 binding partners is shown here. Many interactomes will be disrupted by viruses - there are over 1000
HIV-1/host interactions in the
HIV-1/host interaction database at NCBI and nearly 400 in the
herpes simplex/host database, and about
2,500 different viruses . The same goes for bacteria and other pathogens. In effect, pathogens become a part of our
signalling networks and this is one way in which they contribute to diseases.
Risk factors:
Schizophrenia
Kegg pathways Schizophrenia Herpes simplex infection
HIV-1 Image via Wikipedia
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