As plaques and tangles appear to be repositories for herpes simplex binding proteins and immune related proteins, this would support the idea that they are scar tissue relating to a host/pathogen immune battle Ref
The gamma secretase inhibitor approach has unfortunately not worked and indeed worsened cognition performance in one trial Press release A monoclonal beta-amyloid antibody Bapineuzumab,showed no effect in a phase II trial Salloway et al, 2009 ; and severe amyloid angiopathy has been observed following A beta vaccination Uro-Coste et al, 2010 The trial with the A-beta vaccine AN-1792 was halted due to the development of aseptic meningoencephalitis Alzforum discussion
The amyloid hypothesis has held sway for several years, but has not yielded any fruitful clinical result and a radically new approach is needed.
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