Discovery Links Inflammation to Schizophrenia Onset, May Aid Early Intervention/Prevention | Brain & Behavior Research Foundation (Formerly NARSAD)

Researchers have discovered a protein deficiency that results in mild chronic brain inflammation and is thought to lead to schizophrenia -related symptoms, such as working memory deficits, self-neglect, decreased social behaviors, and the loss of the ability to experience pleasure. An international team collaborated on the work from 11 institutions, including  Tsuyoshi Miyakawa, Ph.D., at the Institute for Comprehensive Medical Science, Fujita Health University and the National Institute for Physiological Sciences, Japan. The results of the study were published in the Feb. 6, 2013 issue of Neuropsychopharmacology


Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia