Thanks
Adding genes and risk factors to the PolygenicPathways database
I have no doubt that many genes and risk factors have not been covered in the PolygenicPathways database and the tidal wave of GWAS data makes it difficult to keep up. If you have new genes and risk factors, could you please help by filling in the form . All I need are gene symbols and the reference or Pubmed ID.
Thanks
Thanks
Hepatitis C virus core protein induces neuroimmune activation and potentiates human immunodeficiency virus-1 neurotoxicity.
Hepatitis C virus core protein induces neuroimmune activation and potentiates human immunodeficiency virus-1 neurotoxicity.
Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination.
Inflammation innate immunity astrocyte demyelination.
Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical
Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes.
Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder
Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder
Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.
Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.
An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis.(increases MS risk)
An updated meta-analysis of risk of multiple scler... [PLoS One. 2010] - PubMed result
".....Our results establish firmly that a history of infectious mononucleosis significantly increases the risk of multiple sclerosis."
".....Our results establish firmly that a history of infectious mononucleosis significantly increases the risk of multiple sclerosis."
Your River of Science - Research RSS Feeds Fulltext Articles - FeedNavigator
Your River of Science - Research RSS Feeds Fulltext Articles - FeedNavigator An astonishing Feed navigator from Terkko in Finland, allowing your own choice of science feeds.
Varying CRP levels in ethnic groups may affect statin eligibility, heart risk prediction
Varying CRP levels in ethnic groups may affect statin eligibility, heart risk prediction An example of how gene variants can influence the effectiveness of drugs. Statins work in some studies but not in others, particularly in Alzheimer's disease (References) , possibly in relation to such interactions
Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations
Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations
Negative data showing the herterogeneity of gene association studies
Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.
Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster.
Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster. This is interesting as it suggests a filament forming role for several proteins, including EIF2B, that are not normally associated with these structures
Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPARγ dependent signal transduction pathways.
Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPARγ dependent signal transduction pathways.
The DISC1 and glutamate interactomes in schizophrenia and bipolar disorder
The 2007 DISC1 interactome is compared with the 2010 update for both schizophrenia and bipolar disorder related genes.
Multiple genes implicated in schizophrenia are also related to the glutamatergic synapse and this is also shown:
Multiple genes implicated in schizophrenia are also related to the glutamatergic synapse and this is also shown:
Tracking down pathogenic yeasts
Tracking down pathogenic yeasts Candida albicans and other usually innocuous yeasts can be dangerous if the immune system is compromised
Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats.
Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats.
Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study
Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study
Scientists find Alzheimer's Disease reduces human brain cancer growth
Scientists find Alzheimer's Disease reduces human brain cancer growth
Cancer is inversely associated with Alzheimer's disease risk, and vice versa Roe et al 2010
Cancer is inversely associated with Alzheimer's disease risk, and vice versa Roe et al 2010
The Pharmacogenomics Journal - A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
The Pharmacogenomics Journal - Abstract of article: A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
Multiple sclerosis: Putting a dampener on inflammation - Cell Signaling Update - Signaling Gateway
Multiple sclerosis: Putting a dampener on inflammation - Cell Signaling Update - Signaling Gateway
Alzforum: Live Discussions: Microdissection and Microarrays: Analyzing Selective Cell Vulnerability
Alzforum: Live Discussions Microdissection and Microarrays: Analyzing Selective Cell Vulnerability
Revealing Malaria's Newest Pathway Into Human Cells
Plasmodium falciparum uses complement receptor 1 to enter erythrocytes: This receptor also binds to Herpes simplex and the influenza virus : Powers et al, 1995
Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir.
Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir.
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.
Schizophrenia Research Forum: DISC1 2010—Development in Flies, Humans, and Mice in Between
Hakon Heimer has put together a number of interesting higlights from the DISC1 conference, which are also available from the Schizophrenia Research Forum site
New gene associated with increased risk of Alzheimer's disease
Image via WikipediaMTHFD1L NCBI Gene
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Alpha- and Beta-Synucleins mRNA Expression in Lymphocytes of Schizophrenia Patients.
Alpha- and Beta-Synucleins mRNA Expression in Lymphocytes of Schizophrenia Patients
Genet Test Mol Biomarkers. 2010Clone|Gene ID Converter
Clone|Gene ID Converter
This is useful for converting the many different gene and protein symbols and accession numbers
This is useful for converting the many different gene and protein symbols and accession numbers
JC virus persistence following progressive multifocal leukoencephalopathy in multiple sclerosis patients treated with natalizumab.
JC virus persistence following progressive multifocal leukoencephalopathy in multiple sclerosis patients treated with natalizumab.
Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.
Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.
Immunoglobulin GM genes as functional risk and protective factors for the development of Alzheimer's disease.
Immunoglobulin GM genes
Many more immune related genes including cytokines, chemokines, Toll receptors, complement cascade components, (Complement receptor 1, C4A, C4B, CFH and clusterin) and HLA antigens are involved in Alzheimer's disease risk, highlighting the importance of immunity and resistance to infection.
Many more immune related genes including cytokines, chemokines, Toll receptors, complement cascade components, (Complement receptor 1, C4A, C4B, CFH and clusterin) and HLA antigens are involved in Alzheimer's disease risk, highlighting the importance of immunity and resistance to infection.
Therapeutic strategies for Alzheimer disease based on endoplasmic reticulum stress
Therapeutic strategies for Alzheimer disease based on endoplasmic reticulum stress
Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study.
Influenza vaccination protects against myocardial infarction (heart attacks)
Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells.
Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells.
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand.
Complement receptor Plasmodium falciparum
It is also a receptor for Herpes simplex and influenza viruses Powers et al, 1995 and also clears Streptococcus Pneumoniae Li et al, 2010
It is also a receptor for Herpes simplex and influenza viruses Powers et al, 1995 and also clears Streptococcus Pneumoniae Li et al, 2010
Integrated Biology: What is needed to bring the Omics together?
Integrated Biology: What is needed to bring the Omics together?
A science webinar from AAAS
A science webinar from AAAS
Microbial Identification_Biolog
Relation between Epstein-Barr virus and multiple sclerosis: analytic study of scientific production.
"This meta-analysis detected an association between infection by the Epstein-Barr virus and MS through the investigation of antibodies, mainly anti-EBNA-1, anti-complex EBNA and anti-VCA IgG".
Severity of experimental autoimmune encephalomyelitis is unexpectedly reduced in mice born to vitamin D-deficient mothers.
Severity of experimental autoimmune encephalomyelitis is unexpectedly reduced in mice born to vitamin D-deficient mothers.
......not much sunlight in the womb !
Association of the clusterin gene polymorphisms with type 2 diabetes mellitus.
Very interesting because of the asociation between diabetes and Alzheimer's disease
Identification of High Risk DISC1 Protein Structural Variants in Patients with Bipolar Spectrum Disorder.
Identification of High Risk DISC1 Protein Structural Variants in Patients with Bipolar Spectrum Disorder.
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition — PNAS
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition — PNAS "..................the spatial distribution of aerobic glycolysis in normal young adults correlates spatially with Aβ deposition in individuals with DAT and cognitively normal participants with elevated Aβ, suggesting a possible link between regional aerobic glycolysis in young adulthood and later development of Alzheimer pathology". CMR glu is reduced prior to discernible symptoms in Alzheimer's disease (Cutler 1986) and correlates with deficits in AD patients Rapoport 1986
Receptor physiology: It's the NMDA receptor, but not as we know it : Nature Reviews Neuroscience
"Unlike most NMDA (N-methyl-D-aspartate) receptor (NMDAR) subunit combinations, which require glycine and glutamate for activation, NMDARs that contain both NR1 and NR3 subunits (NR1/NR3 receptors) are activated by glycine alone. This property and other unusual properties of this receptor subtype were discovered following experiments in recombinant expression systems but had been difficult to demonstrate in vivo"
The promise and reality of pharmacogenetics in psychiatry.
The promise and reality of pharmacogenetics in psychiatry.
Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia.
Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia.
Chlamydia pneumoniae infection as a risk factor for accelerated atherosclerosis in hemodialysis patients.
Image via WikipediaChlamydia pneumoniae infection as a risk factor for accelerated atherosclerosis in hemodialysis patients.
Chlamydia map
Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia.
Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia.
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