Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment.

Cholesterol genes in Alzheimer's
The Apo E Gene Diet: A Breakthrough in Changing Cholesterol, Weight, Heart and Alzheimer's Using the Body's Own Genes

Brain Signs of Schizophrenia Found in Babies

Animal models of virus-induced neurobehavioral sequelae: recent advances, methodological issues, and future prospects.

Apobec 3G Efficiently Reduces Infectivity of the Human Exogenous Gammaretrovirus XMRV.

Treating Multiple Sclerosis With Antihypertensive Drug

Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses.

A number of synapse related genes have been implicated in both bipolar disorder and schizophrenia in pre-GWAS genetic association studies. These are listed at the PolygenicPathways database and a glutamatergic interactome is also available.  Interactome wiki 

Protein?Protein Interaction Prediction: Interactome, Protein?Protein Interaction, Two-Hybrid Screening, Mass Spectrometry, Protein Microarray

APP, APOE, Complement receptor 1, Clusterin and PICALM and their involvement in the Herpes simplex life-cycle

The major Alzheimer’s disease susceptibility genes (APOE, Clusterin, Complement receptor 1 (CR1) and phosphatidylinositol binding clathrin assembly protein, PICALM) can be implicated directly (APOE, CR1) or indirectly (clusterin and PICALM) in the Herpes simplex life cycle. The virus binds to proteoliposomes containing APOE or APOA1 and also to CR1, and both clusterin and PICALM are related to a mannose 6-phosphate receptor used by the virus for cellular entry and intracellular transport. PICALM also binds to a nuclear exportin used by the virus for nuclear egress. Clusterin and complement receptor 1 are both related to the complement pathways and play a general role in pathogen defence. In addition, the amyloid precursor protein APP is involved in Herpes viral transport and gamma-secretase cleaves a number of receptors used by the virus for cellular entry. APOE , APOA1 and clusterin, or alpha 2-macroglobulin, insulysin and caspase 3, which also bind to the virus, are involved in beta-amyloid clearance or degradation, as are the viral binding complement components, C3 and CR1. There are multiple ways in which the products of key susceptibility genes might be able to modify the viral life cycle and in turn the virus interacts with key proteins involved in APP and beta-amyloid processing. These interactions support a role for the Herpes simplex virus in Alzheimer’s disease pathology and suggest that antiviral agents or vaccination might be considered as viable therapeutic strategies in Alzheimer’s disease.
Neuroscience Letters 2010
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Pregnancy infections in mothers of chronic schizophrenic patients. The significance of differential nosology

3D model of an influenza virus.Image via Wikipedia
This is an old paper, but links Schizophrenia in the offspring to influenza and the common cold (rhinovirus) with fever in the mothers during pregnancy
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The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia--the risk factor or an indication of a contact with cat?

None - This image is in the public domain and ...Image via Wikipedia
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Researcher identifies links between hypertension, bipolar disorders | MSU News | Michigan State University


The DASH Diet Action Plan: Based on the National Institutes of Health Research: Dietary Approaches to Stop Hypertension
Clinical Management of Hypertension, 8th Edition

Obesity and Body Shape Linked to Poorer Brain Function in Women

This is in line with the reports that "bad fats" (saturated) increase the risk for dementia and that "good fats" the polyunsaturated kind found in the Mediterranean diet may be beneficial See Alzheimer's disease risk factors for references
Risk Factors for Alzheimer's Disease (A collaborative Re-Analysis of Case Control Studies)
The Mediterranean Diet
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A potential cure for Alzheimer's disease ?

Beta-amyloid and the  mutant APP proteins contain short contiguous amino acid stretches exactly matching those in multiple viruse, phages and bacteria, many of which have been implicated in Alzheimer's disease. These viral matches are often immunogenic and could also target the human proteins, killing the neurones in which they reside by autoimmune activation  inflammatory mechanisms and complement-related lysis. This suggests that immunosuppressants could delay the onset and halt the progression of both late-onset and familial Alzheimer's  disease.
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A cure for Huntington's disease ?

The mutant protein in Huntington's disease and other polyglutamine disorders (spinocerebellar ataxias, Dentatorubropallidoluysian atrophy, Kennedy disease) aligns with immunogenic proteins from very common phages and viruses. Antibodies to these phages and viruses could also target the mutant human protein, killing the cells where it is expressed by autoimmune activation.This suggests that immunosuppressants might delay the onset and prevent the progression of these diseases.

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Low HDL cholesterol is associated with lower gray matter volume in cognitively healthy adults

HDL and LDL Cholesterol: Physiology and Clinical Significance (Biochemistry Research Trends Series)
HDL Cholesterol Management
Managing Cholesterol
Of Bugs & Brains: Caltech Researchers Discover that Gut Bacteria Affect Multiple Sclerosis - Caltech Media Relation...

A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis

Lactobacillus Molecular Biology: From Genomics to Probiotics
Antimicrobial and Antioxidative Probiotic Lactobacillus fermentum ME-3: Technological and Functional Properties
Bacteria for Breakfast: Probiotics for Good Health

Rare infections mimicking MS. [Clin Neurol Neurosurg. 2010]

Multiple sclerosisThe First Year: Multiple Sclerosis: An Essential Guide for the Newly DiagnosedMultiple Sclerosis 
Multiple Sclerosis Q & A: Reassuring Answers to Frequently Asked Questions
Multiple Sclerosis For Dummies
Curing MS: How Science Is Solving the Mysteries of Multiple Sclerosis

Of Bugs & Brains: Caltech Researchers Discover that Gut Bacteria Affect Multiple Sclerosis - Caltech Media Relations

Of Bugs & Brains: Caltech Researchers Discover that Gut Bacteria Affect Multiple Sclerosis - Caltech Media Relations: "- Sent using Google Toolbar"
The geographical distribution of positive and negative gene association data in Alzheimer's disease and schizophren...

The geographical distribution of positive and negative gene association data in Alzheimer's disease and schizophrenia

If there is one factor common to genetic association studies it is their heterogeneity Bertram and Tanzi 2004 Shi et al, 2008 Dozen of confusing positive and negative studies blur the picture and suggest that many are related to artefact or insufficient statistical power. However, while at a global level these results are contentious, at a local level they can be quite homogenous, tending to cluster in positive or negative association hot and coldspots around the world.These examples are taken from data from the Alzgene and Szgene databases and are posted to illustrate this phenomenon.
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