Showing posts with label transposon. Show all posts
Showing posts with label transposon. Show all posts – Rogue DNA busts out of aging cell ‘prison’

As cells age, they lose control over parasitic strands of mobile DNA that insert themselves into chromosomes, new research shows.The parasitic strands of genetic material called transposable elements—transposons—lurk in our chromosomes, poised to wreak genomic havoc. Cells have evolved ways to defend themselves, but in the new study, researchers describe how cells lose this ability as they age, possibly resulting in a decline in their function and health.
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Storm of 'awakened' transposons may cause brain-cell pathologies in ALS, other illnesses

A team of neuroscientists and informatics experts at Cold Spring Harbor Laboratory (CSHL) reports important progress in an effort to understand the relationship between transposons -- sequences of DNA that can jump around within the genome, potentially causing great damage -- and mechanisms involved in serious neurodegenerative disorders including ALS (amyotrophic lateral sclerosis, also known as Lou Gehrig's disease), FTLD (frontotemporal lobar degeneration) and Alzheimer's disease.