In a study published online in Nature Genetics on December 23, the group showed that genetic variations thought to be associated with disease tend to cluster near specific chromatin marks – biochemical modifications of the proteins that package DNA inside the cell. These chromatin marks can serve as a sort of genomic signpost, indicating that gene regulation may be taking place nearby. Raychaudhuri's team found that the clustering around these marks occurs most noticeably in cell types that are related to the disease. This suggests that a comparison of suspected genetic variants and the most useful chromatin marks could help researchers home in on the cell types and regulatory pathways involved in a given disease.
Read more at: http://medicalxpress.com/news/2013-01-chromatin-disease-pathways.html#jCp
Read more at: http://medicalxpress.com/news/2013-01-chromatin-disease-pathways.html#jCp
No comments:
Post a Comment