"when we infected mice first with H. pylori and then 2 months later with influenza A virus, H. pylori colonization densities in the stomachs of individual mice showed a strong positive correlation with the influenza viral loads in their lungs. In other words, knowledge of the H. pylori bacterial load in the stomach could have predicted the influenza viral load in the lung. Weight loss is an indication of influenza severity in mice and is correlated with viral titers ). Interestingly, the H. pylori burden was also highly correlated with weight change after influenza virus infection and, in fact, was a better predictor than the influenza virus titer . Thus, the bacterial load ofH. pylori in the stomach predicts both virologic and clinical outcomes of influenza virus infection among inbred mice. Together, these data suggest that individual inbred mice differ in the capacity to control disparate infections in two distinct tissue compartments".
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