Storm of 'awakened' transposons may cause brain-cell pathologies in ALS, other illnesses

A team of neuroscientists and informatics experts at Cold Spring Harbor Laboratory (CSHL) reports important progress in an effort to understand the relationship between transposons -- sequences of DNA that can jump around within the genome, potentially causing great damage -- and mechanisms involved in serious neurodegenerative disorders including ALS (amyotrophic lateral sclerosis, also known as Lou Gehrig's disease), FTLD (frontotemporal lobar degeneration) and Alzheimer's disease.

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