DNA Methylation Declines with Age | The Scientist

Aging is associated with loss of an epigenetic marker that helps control gene expression, according to new research published in Proceedings of the National Academy of Sciences, with a centenarian carrying some 7 percent fewer methylated DNA bases than a newborn. Researchers posit that reductions in methylation may be one of the mechanisms underlying the aging process.

1 comment:

Dov Henis said...

Update some present AAAS trade-union science concepts:

Why DNA Methylation Declines With Age


DNA methylation declines with age most probably due to RNAs activity decline with age most probably due to decline with age of the circumstantial pressure for physiological adaptation for natural selection…

A.
a)
DNA Methylation Declines With Age
http://the-scientist.com/2012/06/11/dna-methylation-declines-with-age/

b)
1)“RNA molecules are synthesized in the cell nucleus, yet many have to be moved to the cytoplasm to be processed and/or to effect their function. Different classes of RNA are transported from the nucleus by different transport systems.”

2)” Brain volume tended to decrease with subjects' age, consistent with other studies that have found that some brain shrinkage occurs normally as people grow older. But among cocaine users, the rate of shrinkage was almost twice that of the non-drug-using group (about 3 milliliters per year versus 1.7 milliliters for the non-drug-users)”

B.
From “More On Evolution In The Still RNA World “
http://classic.the-scientist.com/community/posts/list/260/122.page#4818

…Rational possibility that the RNAs are the environmental feedback communicators to, and modifiers of, the genomes, the effectors of the desirable biased genes expressions modifications, of enhanced energy constraining for survival.

Dov Henis (comments from 22nd century)
http://universe-life.com/2012/02/03/universe-energy-mass-life-compilation/