Role of amyloid beta as sensors and protectors in Alzheimer's and other diseases explored

Amyloid senses cellular environmental stress, such as elevation of 
reactive metabolites and oxidative products or metals, and then 
misfolds. This misfolding initiates a protective cellular response in 
the short term. Long-term or chronic stress such as metabolic 
dysfunction (diabetes) would lead to the pathological consequences of 
amyloid misfolding (as diabetes is a risk factor for Alzheimer's).

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