Thw data revealed that the transcriptional activation of HERV is associated with the development of schizophrenia in some patients and indicated that HERV-W env regulates the expression of schizophrenia-associated genes.
Implication of the env gene of the human endogenous retrovirus W family in the expression of BDNF and DRD3 and development of schizophrenia
Overexpression of HERV-w env in human U251 glioma cells upregulated
brain-derived neurotrophic factor (BDNF), an important
schizophrenia-associated gene, neurotrophic tyrosine kinase receptor
type 2 (NTRK2, also called TrkB), and dopamine receptor D3 and increased
the phosphorylation of cyclic adenosine monophosphate response
element-binding (CREB) protein
Thw data revealed that the transcriptional activation of HERV is associated with the development of schizophrenia in some patients and indicated that HERV-W env regulates the expression of schizophrenia-associated genes.
Thw data revealed that the transcriptional activation of HERV is associated with the development of schizophrenia in some patients and indicated that HERV-W env regulates the expression of schizophrenia-associated genes.
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