Specific gene linked to cold sore susceptibility, study finds
The gene is of unknown function (C21orf91)
Advance toward a breath test to diagnose multiple sclerosis
Image via WikipediaDetection of Multiple Sclerosis from Exhaled Breath Using Bilayers of Polycyclic Aromatic Hydrocarbons and Single-Wall Carbon Nanotubes
Intestinal microbiota promote enteric virus replication and systemic pathogenesis.
Here one microbiome , the bacterial microbiome, influences another:- in this case the poliovirus and the reovirus, an unrelated enteric virus, whose virulence is affected by antobiotics that destroy the bacteria. Viruses bind to bacterial lipopolysaccharide and exploit intestinal microbes for replication and transmission.
Wheels within wheels.
Wheels within wheels.
Study identifies specific bacteria which precede autoimmune diabetes
A study led by Matej Oresic from VTT Technical Research Centre of Finland suggests that autoimmune diabetes is preceded by diminished gut microbial diversity of the Clostridium leptum subgroup, elevated plasma leptin and enhanced glucose-stimulated insulin secretion.
Air & Asthma -- Pollution Changing Your DNA?
Pollution may be affecting asthma in more ways than one: Firstly by directly provoking pulmonary irritation and secondly by promoting epigenetic chnges in our DNA.
Healthy mouth bacteria provide ideal conditions for gum disease
Gum disease is a risk factor for a number of other diseases, including atherosclerosis and Alzheimer's disease: When the oral bacterium P. gingivalis was introduced under normal conditions it stimulated the growth of normal bugs leading to a large increase in the number of those organisms already there. P. gingivalis was introduced at very low levels but had a major affect on both the immune system and the inflammatory system.
Natural intestinal flora involved in the emergence of multiple sclerosis, study finds
The microbiome influenced the induction and severity of pathology in this mouse model of multiple sclerosis by modulating the immune system. Shotgun sequencing of the multiple sclerosis microbiome should help to identify benign and malevolent bacterial species.
Multiple sclerosis genes and risk factor
Multiple sclerosis genes and risk factor
Antimicrobial Properties of Garlic Compounds are Explored
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Environmental toxin bisphenol A (BPA) can affect newborn brain, mouse study shows
Bisphenol A is found in plastics including baby feeding bottles: In Europe and Canada, BPA use is banned in baby bottles.
Potential new drug target could stop debilitating effects of multiple sclerosis
This concerns preventing granzyme B entry by blocking the mannose-6-phosphate receptor:
Granzyme B is found in multiple sclerosis lesions and promotes apoptosis .
Granzyme B is found in multiple sclerosis lesions and promotes apoptosis .
Simple gut hormone combo makes our brains think we're full
The gut hormones peptide YY and glucagon-like peptide 1 , which are both released into circulation after we eat play a role in appetite control
A review of candidate urinary biomarkers for autism spectrum disorder.
Putative autism biomarkers were identified that could be categorized according to the key theories that exist regarding the etiology of autism: gastrointestinal factors, immune dysregulation, heavy metal toxicity, neurotransmitter abnormalities, and oxidative stress.
Autism risk factors
Autism risk factors
nsf.gov - National Science Foundation (NSF) News - Geoscientists Find Key to Why Some Patients Get Infections from Cardiac Implants - US National Science Foundation (NSF)
Bacterial cells have gene mutations that allow them to 'stick' to the devices
Mood, cognition and sleep patterns improve in Alzheimer's patients after cataract surgery
Researchers at Tenon Hospital, Paris, France, found that patients with mild Alzheimer's disease whose vision improved after cataract surgery also showed improvement in cognitive ability, mood, sleep patterns and other behaviors. Lead researcher Brigitte Girard, MD, will discuss her team's results today at the American Academy of Ophthalmology's 2011 Annual Meeting.
Could additives in hot dogs affect incidence of colon cancer?
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A novel oral treatment for leishmaniasis has potential to save thousands of lives
A tropically stable liquid therapy for leishmaniasis, a disease known as the Baghdad boil, shows a significant decrease in infection after less than a week of treatment. This research is being presented at the 2011 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Washington, D.C., Oct. 23 – 27.
The otologic microbiome:
The otologic microbiome: a study of the bacterial microbiota in a pediatric patient with chronic serous otitis media using 16SrRNA gene-based pyrosequencing.
We detected a total of 17 unique bacterial families, with 9, 9, and 12 bacterial families from the middle ear, tonsil, and adenoid specimens, respectively. Pseudomonadaceae dominated the middle ear microbiota at 82.7% relative abundance, whereas Streptococcaceae dominated the tonsil microbiota at 69.2%. Multiple bacteria, including Pseudomonadaceae, Streptococcaceae, Fusobacteriaceae, and Pasteurellaceae, dominated the adenoid microbiota. Overlap between the middle ear and the tonsil microbiota was minimal. In contrast, the adenoid microbiota encompassed bacteria detected from middle ear and tonsil.CONCLUSIONS:
Bacterial community analysis using pyrosequencing analysis revealed diverse, previously unknown bacterial communities in a set of pediatric middle ear, tonsil, and adenoid specimens. Our findings suggest that the adenoid may be a source site for both the middle ear and tonsil microbiota. An ecological framework is appropriate in comparative analysis of microbiota from nonsterile body sites.
Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action.
Metabolomic profiling
Twenty marker metabolites contributing to the complete separation between post-treatment and pre-treatment patients were identified, with myo-inositol, uric acid and tryptophan showing the maximum combined classification performance.
Schizophrenia
Semen Clusterin Is a Novel DC-SIGN Ligand. [J Immunol. 2011] - PubMed - NCBI
DC-SIGN (CD209) is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes diverse pathogens ranging from parasites to viruses.
GeneNews' Sentinel Principle® Used to Discover New Blood Based Biomarkers for Schizophrenia - FierceBiotech
Several genes that were dysregulated in both individuals with schizophrenia and their siblings related to nucleosome and histone structure and function, suggesting a potential epigenetic mechanism underlying the risk state for the disorder. Nonpsychotic siblings also displayed some differences from comparison subjects that were not found in their affected siblings, suggesting that the dysregulation of some genes in peripheral blood may be indicative of underlying protective factors.
Here's the paper:
Here's the paper:
Study proves new technology kills bacteria
Results from a comprehensive multi-site clinical trial demonstrated that the use of antimicrobial copper surfaces in intensive care unit rooms reduced the amount of bacteria in the rooms by 97 percent and resulted in a 41 percent reduction in the hospital acquired infection rate. According to researchers, this study is one of the first to demonstrate the value of a passive infection control intervention, one that does not rely on staff or patients remembering to take action. The results will be presented on Friday, October 21 at the 2011 Annual Meeting of the Infectious Diseases Society of America in Boston.
PLoS ONE: Benefit from B-Lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-Blind and Placebo-Controlled Study
Rituximab targets and destroy B cells. The B cells are eliminated within weeks , but autoantibodies typically survive in the body for another two or three months. "Washing out these antibodies is the most probable explanation for the time lag in benefits," acccording to the authors.
UK ME Association.
Chronic fatigue genes and risk factors
UK ME Association.
Chronic fatigue genes and risk factors
IMGENEX Webinar |Engineered Reporter Cell Lines for TLR, Innate Immunity, Inflammation and Immune Signaling
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Pollutants linked to 450 percent increase in risk of birth defects in rural China
The pollutants include polycyclic aromatic hydrocarbons , the byproducts of burning fossil fuels such as oil and coal and the pesticides endosulfan and lindane.
Genetic variant and autoantibodies linked to having a child with autism - UC Davis Health System Newsroom
A study by researchers at UC Davis has found that pregnant women with a particular gene variation are more likely to produce autoantibodies to the brains of their developing fetuses and that the children of these mothers are at greater risk of later being diagnosed with autism.
Autism genes risk factors and pathwys
Autism genes risk factors and pathwys
Breastmilk a natural stem cell therapy
Human breastmilk has the potential to help people suffering from diseases including Parkinson's disease and diabetes, according to a researcher at The University of Western Australia.
Phage-bacteria relationships and CRISPR elements revealed by a metagenomic survey of the rumen microbiome.
CRISPR elements are a sort of bacterial immune system - bacteria have to defend themselves against pathogens too.
28,000 different viral genotypes obtained from each environment. The majority (∼78%) of sequences did not match any previously described virus.
Exploring Human Host-Microbiome Interactions in Health and Disease
This new Wellcome Trust Scientific Conference will bring together leading scientists from the fields of microbiology, ecology, immunology, gastroenterology and paediatrics to discuss the latest developments in this fast developing field. Gut microflora play important roles in how we derive energy from our diet and how we store this energy. Recent studies have revealed the extraordinary complexity of the gut microbial ecology and its network connectivity to the metabolic regulation of important pathways in the host. Microbiome abnormalities have been associated with many non-infectious diseases including inflammatory bowel conditions, colonic cancer, autoimmune diseases, diabetes and obesity and autism. Gut microbial activity also plays an important role in drug metabolism and toxicity. Understanding the role of the microbiome will offer new insights into major disease processes and discovery of new therapeutic strategies that either target the microbiome directly or use this information in new stratified medicine approaches. Abstract deadline: 12 March 2012 | Registration deadline: 9 April 2012
Researcher says banned pregnancy drug impacts fetal immune system
(Medical Xpress) -- A synthetic estrogen—diethylstilbestrol (DES)—prescribed to women in the 1940s, 1950s, and 1960s to prevent miscarriages had serious, untoward effects in daughters of these women, including the development of a rare type of cancer of the uterus. There has been renewed interest in light of an Oct. 6 report in the New England Journal of Medicine documenting lifelong health complications facing daughters of women given DES.
Fruit and vegetable compound offers hope against gum disease
(Medical Xpress) -- Scientists at the University of Birmingham have found that supplementing the diet with a special combination of fruit and vegetable juice powder concentrates may help to combat chronic gum disease when combined with conventional dental therapy.
Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects
This is quite a feat
........ ...................a gene-based method for associating the joint effect of single nucleotide polymorphisms (SNPs) in 18,044 genes across 31,662 voxels of the whole brain in 731 elderly subjects
..........or over half the genome and 30,000 endophenotypes
Other Imaging genetics reviews from the Thompson Lab
........ ...................a gene-based method for associating the joint effect of single nucleotide polymorphisms (SNPs) in 18,044 genes across 31,662 voxels of the whole brain in 731 elderly subjects
..........or over half the genome and 30,000 endophenotypes
Other Imaging genetics reviews from the Thompson Lab
Sugar-free sweets and drinks 'may damage dental enamel' - Health News - NHS Choices
Sugar-free sweets and drinks 'may damage dental enamel' - Health News - NHS Choices
Skin's immune peacekeepers discovered
Langerhans cells (not the ones in the pancreas) are skin dendritic cells that play an important role in pathogen defence.
Langerhans cells are precommitted to immune tolerance induction from PNAS
IIntrathecal human herpesvirus 6 antibodies in multiple sclerosis and other demyelinating diseases presenting as oligoclonal bands inCSF
If it's not one virus it's another - in this case the ubiquitous HHV-6
Broccoli-based compound beats drug resistance in lung disease (COPD)
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Nourishing protein (VEGF) slows brain disease (Spinocerebellar ataxia)
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Independent research teams identify first infectious agent associated with colon cancer
This is a type of Fusobacterium which may well be a cause of colon cancer, as Helicobacter pylori is a cause of gastric cancer: The Human papilloma virus causes cervical cancer and others have also been linked to cancer (Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus the Merkel cell polyomavirus , he hepatitis C virus as well as human T-lymphotropic virus (HTLV-1).
Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis.
There appears to be a complex interaction between vitamin D levels and those of antibodies to various viruses in paediatric multiple sclerosis
Temporal relationship between environmental influenza A and Epstein-Barr viral infections and high multiple sclerosis relapse occurrence.
When influenza or Epstein-Barr viral infections were higher in the general population, the incidence of multiple sclerosis relapses also increased.
Multiple sclerosis genes risk factors and pathways
Genetic Factors Influence Serological Measures of Common Infections.
The authors tested heritability for 13 common infections (Chlamydophila pneumoniae, Helicobacter pylori, Toxoplasma gondii, adenovirus 36 , hepatitis A virus, influenza A and B, cytomegalovirus, Epstein-Barr virus, herpes simplex virus (HSV)-1 and -2, human herpesvirus-6, and the varicella zoster virus. Different genetic factors contribute to different infection.
Beneficial gut bacteria can become virus collaborators | Not Exactly Rocket Science | Discover Magazine
The Poliovirus attaches itself to lipopolysaccharide on bacterial cell walls and hitches a ride around the body: Antibiotics can reduce poliovirus infection in mice by killing the bacteria. Many more viruses could exploit this pathway.
Serum antibodies to Toxoplasma gondii and Herpesvidae family viruses in individuals with schizophrenia and bipolar disorder: a case-control study.
This study provides additional evidence that infection with T gondii and the cytomegalovirus may be associated with some cases of schizophrenia and bipolar disorder
Endogenous morphine-like compound immunoreactivity increases in parkinsonism.
Dopamine is a potential precursor for the synthesis of morphine-like compounds : Despite this, the synthesis of such compound is increased in the Parkinson's disease brain.
Pesticide pollution in European waterbodies: List of chemicals to be monitored should be updated immediately, experts urge
Pesticides have been linked to Parkinson's disease and others: Many others , as well as other pollutants, drugs and antibiotics, that we throw down the sink, may also contribute to this growing problem .
Differential transmission and postnatal outcomes in triplets with intrauterine cytomegalovirus infection.
None of the infants had physical or auditory problems at 4 years of age, while the third-born triplet had been diagnosed with an autistic disorder.
The Wired Atlas of the Human Ecosystem | Magazine | Wired.com
A good introduction to the human microbiome
Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation:suppresses experimental multiple sclerosis
A surprisingly direct effect of an unsaturated fatty acid ( Docosahexaenoic acid ) in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis.
Multiple sclerosis genes risk factors and pathways
Multiple sclerosis genes risk factors and pathways
The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22.
or ......... how a virus can disrupt circadian rhythm -
Eating your greens can change the effect of your genes on heart disease
................vegistasis ?
Gut commensal bacteria direct a protective immune response against Toxoplasma gondii.
T.Gondii has been implicated in schizophrenia and other diseases: When treated with broad spectrum antibiotics to kill the intestinal flora, T.Gondii infection in mice worsened and commensal bacteria exerted a protective effect against infection.
Melatonin delays onset, reduces deaths in mouse model of Huntington’s disease
Melatonin is a serotonin derivative See Kegg: Type 1 melatonin receptors are found on mitochondria, which supplies energy for the cell: These are depleted in Huntington's brain samples.
This pathway links in with the kynurenate pathway, also implicated in Huntington's disease.
This pathway links in with the kynurenate pathway, also implicated in Huntington's disease.
Peanut Allergy Turned Off by Tricking Immune System : Northwestern University Newscenter
The peanut tolerance was achieved by attaching peanut proteins onto blood cells and reintroducing them to the body -- an approach that ultimately may be able to target more than one food allergy at a time.
It may well be relavant to other food allergy problems - like gluten inteolerance which has been linked to several conditions (ADHD, and schizophrenia for example).
It may well be relavant to other food allergy problems - like gluten inteolerance which has been linked to several conditions (ADHD, and schizophrenia for example).
Association of attention-deficit/hyperactivity disorder and celiac disease: a brief report.
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Early inhibition of acetylcholinesterase and choline acetyltransferase activity in herpes simplex virus type 1 infection of PC12 cells.
and the date ? .................1984
Identification of the Myelin Oligodendrocyte Glycoprotein as a Cellular Receptor for Rubella Virus
The rubella virus (german measles) has been implicated in a number of diseases, including autism, schizophrenia and multiple sclerosis: All of these are demyelinating conditions and this viral receptor (myelin ologodendrocyte glycoprotein) is expressed on the oligodendrocyte cell surface and on myelin sheaths.
Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology.
When mutant presenilin was transfected into bone marrow cells, the brain pathology of mutant APP or APP/presenilin transgenic mice worsened.
Related articles
Related articles
owards resolving the transcription factor network controlling myelin gene expression.
A nice genomics/bioinformatics study on myelin related genes
PLoS ONE: Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1
PLoS ONE: Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1
The Fox and the Rabbits—Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease
Alzheimer's genes risk factors and pathways
The Fox and the Rabbits—Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease
Alzheimer's genes risk factors and pathways
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