Vascular Contributions to Cognitive Impairment and Dementia
The vascular input to Alzheimer's disease includes carotid artery atherosclerosis Silvestrini and others , which diminishes blood flow to the brain, and also atherosclerosis of the leptomeningeal arteries or of the circle of Willis Roher and others. Reduced cerebral blood flow, hypoxia, hypoglycaemia or ischaemia can all induce beta-amyloid deposition. Review
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