Low body fat may not lower risk for heart disease and diabetes, genetic study shows

A gene that lowers body fat also increased the risk for type 2 diabetes and heart disease: The gene involved   (Insulin receptor substrate 1 IRS1 ) only lowers subcutaneous and not visceral fat: It also unfavourably modifies glucose and cholesterol levels. One gene - many functions of the protein. Nature is complicated, and genes do not have simple single effects.