T-helper cells that produce interleukin-17 (TH17 cells) play a role in autoimmunity: Their development is controlled by retinoic-acid-receptor-related orphan receptors alpha and gamma-T and antagonists of these receptors, Digoxin or SR1001, blocks their development , and reduce cytokine secretion andthe clinical severity of autoimmune disease in mice (experimental encephalomyelitis)
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Multiple sclerosis genes, risk factors and KEGG pathways
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