Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms.

This effect may be related to the tryptophan defense pathway: Many microbes depend on tryptophan as a nutrient and turning on its degradation by Indoleamine 2,3-dioxygenase is one means of defence.This also has effects on the metabolism of the NMDA antagonist kynurenic acid



Risk factors: Alzheimer's : Autism : Bipolar disorder : Childhood obesity: Chronic fatigue: Multiple sclerosis Parkinson's disease Schizophrenia Kegg pathways Alzheimer's Parkinson's Schizophrenia Herpes simplex infection Cystic fibrosis CFTR interactome