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Bacteria provide example of one of nature's first immune systems, research shows
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Trace amounts of microbe-killing molecules predict chronic granulomatous disease survival
Trace amounts of microbe-killing molecules predict chronic granulomatous disease survival
Search Amazon.com for chronic granulomatous disease
Search Amazon.com for chronic granulomatous disease
Kegg pathway analysis of over 400 Alzheimer's disease susceptibility genes
Over 400 Alzheimer’s disease susceptibility genes have been recorded in association studies.This Kegg pathway analysis shows that these genes trace out a number of signalling networks that are highly relevant to the sub-pathologies of Alzheimer’s disease. These genes are colour-coded yellow while genes also involved in the herpes simplex life cycle are coded red.
These pathways include the APP processing pathway as well as apoptosis and oxidative stress related networks. Pathways involved in glycolysis, the Krebs cycle and oxidative phosphorylation are also implicated, a testament to the problems in cerebral energy metabolism, observed in Alzheimer’s disease.
Numerous immune and pathogen defence pathways are involved, as are a number of clearly defined pathogen entry pathways. Some of the more exotic pathways, for example Chaga’s disease and amoebiasis should perhaps be considered as generic rather than specific, indicating general routes for pathogen entry. These pathways tie in with the diverse viral, bacterial and other pathogens that have been implicated as Alzheimer’s disease risk factors( e.g. Chlamydia , C.Neoformans, herpes simplex or helicobacter pylori) See database
Despite the problems of replication, these genes, collected over decades of genetic association studies, tell a story that illustrates the aetiology of Alzheimer’s disease. The pathways etched out by these genes are relevant to many of the processes known to be disrupted in this disorder, and also to the pathogenic environmental risk factors.
Other Kegg pathways
These pathways include the APP processing pathway as well as apoptosis and oxidative stress related networks. Pathways involved in glycolysis, the Krebs cycle and oxidative phosphorylation are also implicated, a testament to the problems in cerebral energy metabolism, observed in Alzheimer’s disease.
Numerous immune and pathogen defence pathways are involved, as are a number of clearly defined pathogen entry pathways. Some of the more exotic pathways, for example Chaga’s disease and amoebiasis should perhaps be considered as generic rather than specific, indicating general routes for pathogen entry. These pathways tie in with the diverse viral, bacterial and other pathogens that have been implicated as Alzheimer’s disease risk factors( e.g. Chlamydia , C.Neoformans, herpes simplex or helicobacter pylori) See database
Despite the problems of replication, these genes, collected over decades of genetic association studies, tell a story that illustrates the aetiology of Alzheimer’s disease. The pathways etched out by these genes are relevant to many of the processes known to be disrupted in this disorder, and also to the pathogenic environmental risk factors.
Other Kegg pathways
The herpes simplex virus type 1 latency associated transcript (LAT) can protect neuronal derived C1300 and Neuro2A cells from Granzyme B apoptosis
During latency, herpes simplex appears to have cytoprotective properties, an adaptive feature that enables the virus to stay within infected cells. Harnessing this property may be useful in herpes related diseases, for example Alzheimer's disease.
Herpes life cycle
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Herpes life cycle
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Scientists ID Key Protein That Links Dietary Restriction With Healthy Hearing, Aging
Calorie restriction is known to have anti-ageing properties. A mitochondrial sirtuin, Sirt3 is involved in this process and when knocked out , calorific restricion loses its anti-ageing powers.
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Search Amazon.com for caloric restriction
Gene breakthrough in diabetes study - Yahoo! News UK
Metformin is taken by many diabetics. Curiously, a genetics study identified Ataxia Telangiectasia Mutated (ATM) a DNA damage response gene as a key player in its mechanism of action
Kegg pathways
Kegg pathways
A hundred-year-old insight into the gut microbiome!
An estimated 10 to 100 trillion (1013-1014) bacteria and archaea inhabit the human gut as well as the 1014-1015 associated bacteriophages not to mention other viruses and other parasitic microbes.
We are not alone ! These flora contribute to health and disease, and are as much a part of us as our own cells and tissues. Microbiomes are justifiably a new hot research topic
We are not alone ! These flora contribute to health and disease, and are as much a part of us as our own cells and tissues. Microbiomes are justifiably a new hot research topic
EPO treatment preserves gray matter in discrete brain regions of chronic schizophrenic patients: indication of areas with most progressive neurodegeneration inherent to the disease process
Recombinant human erythropoietin a hematopoietic growth factor delays loss of gray matter in chronic schizophrenia
This is a very important paper, treating schizophrenia as a neurodegenerative disease and a welcome change from neuroleptics.The effects on ongoing gray matter loss are impressive.
Thompson lab videos on gray matter loss
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This is a very important paper, treating schizophrenia as a neurodegenerative disease and a welcome change from neuroleptics.The effects on ongoing gray matter loss are impressive.
Thompson lab videos on gray matter loss
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The cancer-causing chemical, Chromium-6 Is Widespread in US Tap Water | Environmental Working Group
Chromium-6 Is Widespread in US Tap Water | Environmental Working Group
When will we ever learn ? Obesity and aspartame, autism and exhaust fumes , ecstasy and holes in the brain , Pesticides and Parkinson's disease , Cholesterol diet and atherosclerosis or Alzheimer's,
preventable prenatal infection in schizophrenia
............... and so on
Where should the research funds be going ?
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When will we ever learn ? Obesity and aspartame, autism and exhaust fumes , ecstasy and holes in the brain , Pesticides and Parkinson's disease , Cholesterol diet and atherosclerosis or Alzheimer's,
preventable prenatal infection in schizophrenia
............... and so on
Where should the research funds be going ?
Powered by Disqus
Life Science Webinar Series - FEI Company: 3D Electron microscopy
Electron microscopy has come a long way and is now able to visalise in 3-D , providing some amazing images of cells, intracellular components and proteins
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Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity.
This group has developed a very useful high-throughput screening method that allows the rapid identification of compounds that inhibit or activate the Hepatitis C virus. Its application to this and other viruses will be extremely useful.
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Search Amazon.com Books for Hepatitis C virus
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Human herpesvirus 6 infection as a trigger of multiple sclerosis.
Human herpesvirus 6 infection as a trigger of multiple sclerosis.
Multiple sclerosis risk factor database
Multiple sclerosis risk factor database
In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: An approach to their mechanisms of action.
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The World Congress of Neurology: Marrakesh: November 2011
ABSTRACT TOPICS WILL INCLUDE:
| • Dementia | • History of neuroscience |
| • Autonomic disorders | • Movement disorders |
| • Clinical neurophysiology | • Multiple Sclerosis and related |
| • Epilepsy | • Neuroimmunology |
| • Ethics, pain and palliative care | • Sleep Disorders Search Amazon.com Books for Marrakesh |
Scientists find gene clue to 130 brain diseases - Yahoo! News UK
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Interesting datasets can be found at the Genes2Cognition website
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Cancer Patients Are At An Almost Five-Fold Increased Risk Of Developing Listeria
Cancer Patients Are At An Almost Five-Fold Increased Risk Of Developing Listeria
I wonder if this should read the other way around ?
Search Amazon.com Books for bacteria and cancer
I wonder if this should read the other way around ?
Search Amazon.com Books for bacteria and cancer
Parasite (T.Gondii) and bacterium (Chlamydia trachomatis) illustrate convergent evolution: Both hijack cells' 'post office'
Toxoplasma gondii and Chlamydia trachomatis both use the cell's golgi network to capture cell nutrients; T.Gondii localises close to the pericentriolar material - a favoured locale of DISC1 and certain of its binding partners.
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Search Amazon.com for toxoplasmosis
Garlic could protect against hip osteoarthritis
Osteoarthritis Image via WikipediaSearch Amazon.com for Garlic
New study suggests almonds may help reduce risk of type 2 diabetes and heart disease
Ischaemic heart disease map via WikipediaSearch Amazon.com for almonds
Pharmaceuticals In Drinking Water A Serious Problem
The problem of pharmaceticals in drinking water, ingested by animals and ourselves is serious problem. The presence of antibiotics could cause bacterial resistance and oestrogens can cause feminisation in fish and Man
Our Microbial SelvesProjects to tabulate communities of bacteria that cohabit our bodies reveal unexpected roles in health and disease
Millions of diverse bacteria, specifically located in different areas of the body, may be able to cause or protect against a variety of diseases. Understanding these microbiomes is a key area for future research, as - or perhaps more important than genome wide association studies.
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Search Amazon.com for microbiome
Is Ecstasy an “Empathogen”? Effects of ±3,4-Methylenedioxymethamphetamine on Prosocial Feelings and Identification of Emotional States in Others
Effects of ±3,4-Methylenedioxymethamphetamine on Prosocial Feelings and Identification of Emotional States
The authors suggest using ecstasy in psychotherapy:
However there are numerous studies showing that MDMA has neurotoxic effects, surely reason enough to caution against this. Rss feed
The authors suggest using ecstasy in psychotherapy:
However there are numerous studies showing that MDMA has neurotoxic effects, surely reason enough to caution against this. Rss feed
Alzheimer's disease gene signature says: beware of brain viral infections.
This is an important and interesting study, partitioning GWAS data, suggesting that several Alzheimer's disease susceptibility genes are related to viral defense.
As many AD genes are involved in the herpes simplex life cycle Ref and plaques appear to be repositories for herpes simplex binding proteins Ref the evidence for viral involvement is rapidly gaining ground.
Regular viral screening in the ageing population and the use of available antivirals may be of clinical benefit.
Search Amazon.com for herpes simplex
As many AD genes are involved in the herpes simplex life cycle Ref and plaques appear to be repositories for herpes simplex binding proteins Ref the evidence for viral involvement is rapidly gaining ground.
Regular viral screening in the ageing population and the use of available antivirals may be of clinical benefit.
Search Amazon.com for herpes simplex
Neonatally measured immunoglobulins and risk of autism.
The authors suggest that maternal immune dysfunction during pregnancy may impact on the development of autism
Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD.
The complement membrane attack complex has also been shown to be present in neurones Itagaki et al, 1994
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Search Amazon.com for complement pathway
Gut inflammation provides a respiratory electron acceptor for Salmonella. - F1000
Far from being adversely affected by inflammatory defense , Salmonella thrives on it and uses the molecules generated for respiration.
It's time for a new approach to Alzheimer's disease
Rutger's Herrup thinks that plaques are a symptom and not the cause:
As plaques and tangles appear to be repositories for herpes simplex binding proteins and immune related proteins, this would support the idea that they are scar tissue relating to a host/pathogen immune battle Ref
The gamma secretase inhibitor approach has unfortunately not worked and indeed worsened cognition performance in one trial Press release A monoclonal beta-amyloid antibody Bapineuzumab,showed no effect in a phase II trial Salloway et al, 2009 ; and severe amyloid angiopathy has been observed following A beta vaccination Uro-Coste et al, 2010 The trial with the A-beta vaccine AN-1792 was halted due to the development of aseptic meningoencephalitis Alzforum discussion
The amyloid hypothesis has held sway for several years, but has not yielded any fruitful clinical result and a radically new approach is needed.
As plaques and tangles appear to be repositories for herpes simplex binding proteins and immune related proteins, this would support the idea that they are scar tissue relating to a host/pathogen immune battle Ref
The gamma secretase inhibitor approach has unfortunately not worked and indeed worsened cognition performance in one trial Press release A monoclonal beta-amyloid antibody Bapineuzumab,showed no effect in a phase II trial Salloway et al, 2009 ; and severe amyloid angiopathy has been observed following A beta vaccination Uro-Coste et al, 2010 The trial with the A-beta vaccine AN-1792 was halted due to the development of aseptic meningoencephalitis Alzforum discussion
The amyloid hypothesis has held sway for several years, but has not yielded any fruitful clinical result and a radically new approach is needed.
Asthma mould 'discovered in lungs' - Yahoo! News UK
The mould is Aspergillus fumigatus, usually found in soil and compost heaps.
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Search Amazon.com for Asthma
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