Observations: Alpha-carotene from veggies linked to longer life

alpha-carotene


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Bacteria provide example of one of nature's first immune systems, research shows

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Over millions of years, bacteriophage viral DNA incorporated into bacterial chromosomes becomes a part of the bacterial genome, helping to create new genes that are useful for bacterial defense.
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Gene protects against dementia in high-risk individuals, study finds

Gene protects against dementia in high-risk individuals, study finds

Trace amounts of microbe-killing molecules predict chronic granulomatous disease survival

Trace amounts of microbe-killing molecules predict chronic granulomatous disease survival


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Kegg pathway analysis of over 400 Alzheimer's disease susceptibility genes

Over 400 Alzheimer’s disease susceptibility genes have been recorded in association studies.This Kegg pathway analysis shows that these genes trace out a number of signalling networks that are highly relevant to the sub-pathologies of Alzheimer’s disease. These genes are colour-coded yellow while genes also involved in the herpes simplex life cycle are coded red.

These pathways include the APP processing pathway as well as apoptosis and oxidative stress related networks. Pathways involved in glycolysis, the Krebs cycle and oxidative phosphorylation are also implicated, a testament to the problems in cerebral energy metabolism, observed in Alzheimer’s disease.
Numerous immune and pathogen defence pathways are involved, as are a number of clearly defined pathogen entry pathways. Some of the more exotic pathways, for example Chaga’s disease and amoebiasis should perhaps be considered as generic rather than specific, indicating general routes for pathogen entry. These pathways tie in with the diverse viral, bacterial and other pathogens that have been implicated as Alzheimer’s disease risk factors( e.g. Chlamydia , C.Neoformans, herpes simplex or helicobacter pylori) See database

Despite the problems of replication, these genes, collected over decades of genetic association studies, tell a story that illustrates the aetiology of Alzheimer’s disease. The pathways etched out by these genes are relevant to many of the processes known to be disrupted in this disorder, and also to the pathogenic environmental risk factors.

Other Kegg pathways
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'Good Clostridia' in the Gut Protect from Allergy and Autoimmunity - Applied Clinical Trials

'Good Clostridia' in the Gut Protect from Allergy and Autoimmunity - Applied Clinical Trials Powered by Disqus

Component in common dairy foods may cut diabetes risk, study suggests

Component in common dairy foods may cut diabetes risk, study suggests Powered by Disqus

Pathogenica Awarded CRADA to Develop Pathogen Identification Technology | GenomeWeb Daily News | DxPGx | GenomeWeb

Pathogenica Awarded CRADA to Develop Pathogen Identification Technology | GenomeWeb Daily News | DxPGx | GenomeWeb Powered by Disqus

XMRV and CFS – It’s not the end

XMRVImage by AJC1 via Flickr
Other XMRV posts
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Mammalian aging process linked to overactive cellular pathway

Vaccine For Diabetes | Medical News and Health Information

Unraveling The Cause Of Autism | Medical News and Health Information

Unraveling The Cause Of Autism | Medical News and Health Information Powered by Disqus

Secrets of Epstein Barr Virus Uncovered | Medical News and Health Information

Secrets of Epstein Barr Virus Uncovered | Medical News and Health Information Powered by Disqus

New gut bacteria regulate immunity - The Scientist - Magazine of the Life Sciences

New gut bacteria regulate immunity - The Scientist - Magazine of the Life Sciences Powered by Disqus

You are what your father ate, too: Paternal diet affects lipid metabolizing genes in offspring, research suggests

You are what your father ate, too: Paternal diet affects lipid metabolizing genes in offspring, research suggests Powered by Disqus

Epigenetic phenomena linked to diabetic complications : Article : Nature Reviews Endocrinology

Epigenetic phenomena linked to diabetic complications : Article : Nature Reviews Endocrinology Powered by Disqus

EPO treatment preserves gray matter in discrete brain regions of chronic schizophrenic patients: indication of areas with most progressive neurodegeneration inherent to the disease process

Recombinant human erythropoietin a hematopoietic growth factor delays loss of gray matter in chronic schizophrenia

This is a very important paper, treating schizophrenia as a neurodegenerative disease and a welcome change from neuroleptics.The effects on ongoing gray matter loss are impressive.

Thompson lab videos on gray matter loss




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Is XMRV a laboratory contaminant?

Is XMRV a laboratory contaminant? Powered by Disqus

Cellular mechanism responsible for chronic inflammation, type 2 diabetes uncovered

Cellular mechanism responsible for chronic inflammation, type 2 diabetes uncovered Powered by Disqus

Blue-green algae tested for treating amyotrophic lateral sclerosis

Blue-green algae tested for treating amyotrophic lateral sclerosis Powered by Disqus

Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains.

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The cancer-causing chemical, Chromium-6 Is Widespread in US Tap Water | Environmental Working Group

Chromium-6 Is Widespread in US Tap Water | Environmental Working Group

When will we ever learn ?  Obesity and aspartame, autism and  exhaust fumesecstasy and holes in the brain , Pesticides and Parkinson's disease , Cholesterol diet and atherosclerosis or  Alzheimer's,
preventable prenatal infection in schizophrenia
............... and so on

Where should the research funds be going ?


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Life Science Webinar Series - FEI Company: 3D Electron microscopy

Electron microscopy has come a long way and is now able to visalise in 3-D , providing some amazing images of cells, intracellular components and proteins

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Human immune system has emergency backup plan

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Link between depression and inflammatory response found in mice: New treatments for mood disorders?

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Your genome in minutes: New technology could slash sequencing time

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Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity.

This group has developed a very useful high-throughput screening method that allows the rapid identification of compounds that inhibit or activate the Hepatitis C virus. Its application to this and other viruses will be extremely useful.


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Human herpesvirus 6 infection as a trigger of multiple sclerosis.

Human herpesvirus 6 infection as a trigger of multiple sclerosis.


Multiple sclerosis risk factor database

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer.

celastrol
Thunder of God Vine

Five a day 'saves lives' - Health News - NHS Choices

In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: An approach to their mechanisms of action.

Tansy (Tanacetum vulgare)Image via Wikipedia
Tanacetum vulgare, commonly known as tansy shows activity against HSV-1 and HSV-2
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Three-quarters of hip fracture patients are vitamin D deficient, Indian study reveals

Three-quarters of hip fracture patients are vitamin D deficient, Indian study reveals Powered by Disqus

Beetroot juice could help people live more active lives

Beetroot juice could help people live more active lives Powered by Disqus

The World Congress of Neurology: Marrakesh: November 2011

ABSTRACT TOPICS WILL INCLUDE:
  • Dementia   • History of neuroscience
  • Autonomic disorders   • Movement disorders
  • Clinical neurophysiology   • Multiple Sclerosis  and related
  • Epilepsy   • Neuroimmunology
  • Ethics, pain and palliative care   • Sleep Disorders



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Unraveling The Cause Of Autism | Medical News and Health Information

Unraveling The Cause Of Autism | Medical News and Health Information Powered by Disqus

Alzheimer's disease plaques and tangles: Cemeteries of a Pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation–mediated neuronal destruction



An online version of this paper is avaliable here

Autism And Traffic Pollution Link Found

Autism

Other environmental risk factors



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Novel Drug Offers Hope For Early Intervention In Cystic Fibrosis Patients

Cystic fibrosis

Cholesterol Compound Link To Multiple Sclerosis Unlikely, Researchers Say

Oxysterols

Scientists find gene clue to 130 brain diseases - Yahoo! News UK

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The proteins involved belong to the post-synaptic density, a structure anchoring and controlling glutamate receptors and others at the post-synaptic membrane : This has already been implicated in schizophrenia
Pathway

Interesting datasets can be found at the Genes2Cognition website

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Allergy Treatment May Cause New Allergy

Allergy Treatment May Cause New Allergy

Human fetal immune system arises from entirely different source than adult immune system

Human fetal immune system arises from entirely different source than adult immune system

Garlic could protect against hip osteoarthritis

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Garlic could protect against hip osteoarthritis



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New study suggests almonds may help reduce risk of type 2 diabetes and heart disease

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New study suggests almonds may help reduce risk of type 2 diabetes and heart disease



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Pharmaceuticals In Drinking Water A Serious Problem

The problem of pharmaceticals in drinking water, ingested by animals and ourselves is serious problem. The presence of antibiotics could cause bacterial resistance and oestrogens can cause feminisation in fish and Man

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Our Microbial SelvesProjects to tabulate communities of bacteria that cohabit our bodies reveal unexpected roles in health and disease

Millions of diverse bacteria, specifically located in  different areas of the body, may be able to cause or protect against a variety of diseases. Understanding these microbiomes is a key area for future research, as - or perhaps more important than genome wide association studies.

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IRB Barcelona News - Scientific - Scientists identify the largest network of protein interactions related to Alzheimer’s disease


Is Ecstasy an “Empathogen”? Effects of ±3,4-Methylenedioxymethamphetamine on Prosocial Feelings and Identification of Emotional States in Others

Effects of  ±3,4-Methylenedioxymethamphetamine on Prosocial Feelings and Identification of Emotional States

The authors suggest using ecstasy in psychotherapy:

However there are numerous studies showing that MDMA has neurotoxic effects, surely reason enough to caution against this.   Rss feed

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Alzheimer's disease gene signature says: beware of brain viral infections.

This is an important and interesting study, partitioning GWAS data, suggesting that several Alzheimer's disease susceptibility genes are related to viral defense.

As many AD genes are involved in the herpes simplex life cycle Ref and plaques appear to be repositories for herpes simplex binding proteins Ref  the evidence for viral involvement is rapidly gaining ground.

Regular viral screening in the ageing population and the use of available antivirals may be of clinical benefit.


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Neonatally measured immunoglobulins and risk of autism.

The authors suggest that maternal immune dysfunction during pregnancy may impact on the development of autism

Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD.

The complement membrane attack complex has also been shown to be present in neurones Itagaki et al, 1994


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Gut inflammation provides a respiratory electron acceptor for Salmonella. - F1000

Far from being adversely affected by inflammatory defense , Salmonella thrives on it and uses the molecules generated for respiration.
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It's time for a new approach to Alzheimer's disease

Rutger's Herrup thinks that  plaques are a symptom and not the cause:


As plaques and tangles appear to be repositories for herpes simplex binding proteins and immune related proteins, this would support the idea that they are scar tissue relating to a host/pathogen immune battle Ref

The gamma secretase inhibitor approach has unfortunately not worked and indeed worsened cognition performance in one trial  Press release  A monoclonal beta-amyloid antibody Bapineuzumab,showed no effect in a phase II trial  Salloway et al, 2009 ; and severe amyloid angiopathy has been observed following A beta vaccination  Uro-Coste et al, 2010 The trial with the A-beta vaccine AN-1792 was halted due to the development of aseptic meningoencephalitis  Alzforum discussion 

The amyloid hypothesis has held sway for several years, but has not yielded any fruitful clinical result and a radically new approach is needed. 
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