Healthcare Inputs / Interactive Map / Health of Nations
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Autoantibodies to the adenosine triphosphate synthase play a pathogenetic role in Alzheimer's disease.
adenosine triphosphate synthase autoantibodies play a pathogenetic role in Alzheimer's disease
Typical PET scans for brain hypometabolism in Alzheimer's disease can be found here
Typical PET scans for brain hypometabolism in Alzheimer's disease can be found here
The meta-analysis of T.Gondii antibodies in schizophrenia
Image of parasitic and infectious diseases via WikipediaWith odds ratios like these, who needs genes, especially in China ?!
Olive oil protects liver from oxidative stress, rat study finds
Olive oil protects liver from oxidative stress, rat study finds. One more benefit of the mediteranean diet ?
Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology.
Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology.
Expression of human A53T alpha-synuclein in the rat substantia nigra (modelsParkinson's disease)
Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease.
PRO-MINE: PROtein Mutations In NEurodegeneration A bioinformatics repository and analytical tool for TDP-43 mutations.
PRO-MINE: PROtein Mutations In NEurodegeneration
A bioinformatics repository and analytical tool for TDP-43 mutations.
An aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrils.
An aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrils.
Microbes can be beneficial as well.
Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts.
Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts.
Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
This study confirmed APOE , clusterin , complement receptor 1 and PICALM, and also angiotensin converting enzyme ACE and cystatin CST3 as Alzheimer's disease risk factors
However, note that PICALM did not turn up positive in a chinese study Yu et al, 20101 supporting the notion that genetic associations may cluster in geographical hot and cold spots. See database
However, note that PICALM did not turn up positive in a chinese study Yu et al, 20101 supporting the notion that genetic associations may cluster in geographical hot and cold spots. See database
Health A-Z - Conditions and treatments - NHS Choices
A useful site with information about a variety of diseases and conditions.
Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice -- Jang et al. 140 (10): 1892 -- Journal of Nutrition
Pregnancy timing may influence a child's allergies - Health News - NHS Choices
Pregnancy timing may influence a child's allergies - Health News - NHS Choices
Top 7 Biology papers From F1000 - The Scientist - Magazine of the Life Sciences
Includes papers on diabetes , the Krebs cycle in malaria parasites , how gene selection protecting against one disease can lead to another, and how neurones grow.
Molecular characterization of the evolution of phagosomes
Phagosomes are important in pathogen defense (they kill microbes) and also in initiating a sustained immune response.
Is our too clean culture making our kids sick?
See this article on the hygiene hypothesis
"A little bit of dirt never did anybody any harm............
In fact it may be essential for correct immune balance
"A little bit of dirt never did anybody any harm............
In fact it may be essential for correct immune balance
Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
Rare infections mimicking multiple sclerosis
Whipple's disease, Lyme disease, Syphilis, AIDS, Brucellosis, HHV-6 infection, Hepatitis C, Mycoplasma and Creutzfeld-Jacob disease, Cat scratch disease Bartonella hensellae, Mediterranean spotted fever Riketssia connore and Leptospirosis
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases.
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases.
This is an old paper but very much in line with the theme that infections can have dramatic effects on behaviour.
The importance of the development of the intestinal microbiota in infancy.
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YouTube - cellix ltd's Channel
YouTube - cellixltd's Channel
So far, useful videos on thrombosis, inflammation and atherosclerosis
Is There a Liberal Gene? : Discovery News
This liberal gene is the dopamine receptor DRD4 gene: This has also been implicated in schizophrenia, although not in the USA . The flood of GWAS studies is likely to uncover many more strange but true associations.
NIH - Health Information
A good site for all sorts of health and research information related to many diseases
Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia.
Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia.
Non-coding small (micro) RNAs of Pseudomonas aeruginosa isolated from clinical isolates from adult patients with cystic fibrosis.
Non-coding small microRNAs of Pseudomonas aeruginosa isolated from clinical isolates from adult patients with cystic fibrosis.
Epstein Barr Virus-Encoded EBNA1 Interference with MHC Class I Antigen Presentation Reveals a Close Correlation between mRNA Translation Initiation an
Image via WikipediaEpstein Barr Virus-Encoded EBNA1 Interference with MHC Class I Antigen Presentation Reveals a Close Correlation between mRNA Translation Initiation and Antigen Presentation.
virology blog — About viruses and viral disease
virology blog — About viruses and viral disease
A useful blog about viruses and microbiology
New class of biomolecules triggered in response to respiratory virus infection
Non-coding RNA's that are not translated to protein, and that are larger than microRNA have an important role to play in host pathogen interactions
The environment and susceptibility to schizophreni... [Prog Neurobiol. 2010] - PubMed result
Environmental risk factors in schizophrenia are caralougues at this database
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.
A useful insight into the role of the APP intracellular domain
The pathogenesis of murine coronavirus infection of the central nervous system.
A useful mouse model for multiple sclerosis
New regulator of circadian clock identified: Dopamine study may have impact on activity and sleep rhythms in Parkinson's disease
New regulator of circadian clock identified: Dopamine study may have impact on activity and sleep rhythms in Parkinson's disease
Interesting, as circadian genes have been implicated in both Bipolar disorder and schizophrenia Database
Interesting, as circadian genes have been implicated in both Bipolar disorder and schizophrenia Database
Bitter Taste Receptor Found In Lungs
This may later be useful in diseases like asthma, bronchitis and emphysema, and perhaps cystic fibrosis
Study identifies potential stroke triggers | Reuters
This is interesting as it identifies the triggers immediately prior to a stroke - these include infection and alcohol consumption.
Dementia in Swedish Twins: Predicting Incident Cases
Which twin would develop dementia was predicted by less favorable lipid values (higher apoB, ratio of apoB to apoA1, and total cholesterol
This genetics paper is also very relevant A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
Cholesterol and lipoprotein related genes are listed here
This genetics paper is also very relevant A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
as is this paper Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis.
A Parkinson's disease environmental risk factor database
Parkinson's disease is one of the few diseases where the laboratory models faithfully match the environmental risk factors in the clinical setting. For example MPTP, rotenone or paraquat can all produce dopaminergic lesions in rodents or monkeys, as can infection with the influenza H5N1 virus in mice (see posts). This database sets out to curate the multiple risk and protective factors that have been implicated in the human condition.
Risk factors can be added via the comments section on this post, or via a form on the website.
Risk factors can be added via the comments section on this post, or via a form on the website.
A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
Molecular Psychiatry - Abstract of article: A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
Latrophilins are receptors for a spider venom, latrotoxin
Latrophilins are receptors for a spider venom, latrotoxin
STEP : Abstract : UCSD-Nature Molecule Pages
STEP is a key mediator regulating glutamate, dopamine and adrenaline signalling .
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