MITOP2: Database for mitochondria-related genes, proteins and diseases

mitop project

Effects of Atypical Infections with Mycoplasma and Chlamydia on Asthma

Effects of Atypical Infections with Mycoplasma and Chlamydia on Asthma
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Healthcare Inputs / Interactive Map / Health of Nations

over 80 77.5-80.0 75.0-77.5 72.5-75.0 70.0-72....Image via Wikipedia
Global maps of life expectancies, cardiovasular risk , smoking, hospital care, etc etc:    Very interesting
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HealthMap | Global health, local information on current infections

HealthMap | Global health, local information

Autoantibodies to the adenosine triphosphate synthase play a pathogenetic role in Alzheimer's disease.

adenosine triphosphate synthase autoantibodies play a pathogenetic role in Alzheimer's disease

Typical PET scans for brain hypometabolism in Alzheimer's disease can be found here 
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The meta-analysis of T.Gondii antibodies in schizophrenia

Age-standardised disability-adjusted life year...Image of parasitic and infectious diseases  via Wikipedia
I stumbled accross this while looking for something else, but it merits attention:  From Torrey et al, 2007 Toxoplasmosis T.Gondii

With odds ratios like these, who needs genes, especially in China ?! 
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Olive oil protects liver from oxidative stress, rat study finds

Olive oil protects liver from oxidative stress, rat study finds. One more benefit of the mediteranean diet ?
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Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology.

Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology.

Expression of human A53T alpha-synuclein in the rat substantia nigra (modelsParkinson's disease)

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease.

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PRO-MINE: PROtein Mutations In NEurodegeneration A bioinformatics repository and analytical tool for TDP-43 mutations.

PRO-MINE: PROtein Mutations In NEurodegeneration

A bioinformatics repository and analytical tool for TDP-43 mutations.
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An aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrils.

An aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrils.

 Microbes can be beneficial as well.

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Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts.

Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts.

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Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.

This study confirmed APOE , clusterin , complement receptor 1 and PICALM, and also angiotensin converting enzyme ACE and cystatin CST3 as Alzheimer's disease risk factors

However, note that PICALM did not turn up positive in a chinese study Yu et al, 20101  supporting the notion that genetic associations may cluster in geographical hot and cold spots.  See database
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Health A-Z - Conditions and treatments - NHS Choices

A useful site with information about a variety of diseases and conditions.

J.B.S. Haldane's original treatise on the origin of life : written nearly a century ago

Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice -- Jang et al. 140 (10): 1892 -- Journal of Nutrition

LuteolinImage via Wikipedia
Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice -- Jang et al. 140 (10): 1892 -- Journal of Nutrition

Luteolin is a compound in celery
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Pregnancy timing may influence a child's allergies - Health News - NHS Choices

Pregnancy timing may influence a child's allergies - Health News - NHS Choices

Top 7 Biology papers From F1000 - The Scientist - Magazine of the Life Sciences

Includes papers on diabetes , the Krebs cycle in malaria parasites , how gene selection protecting against one disease can lead to another, and how neurones grow.
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Huge 'biobank' for research into major diseases to be set up

Huge 'biobank' for research into major diseases to be set up

Molecular characterization of the evolution of phagosomes

Phagosomes are important in pathogen defense (they kill microbes) and also in initiating a sustained immune response.
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Protein preserves delicate balance between immune response and host

The protein is CEACAM1 which is also a  bacterial and viral receptor Voges et al, 2010   RSS feed
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Is our too clean culture making our kids sick?

See this article on the hygiene hypothesis

"A little bit of dirt never did anybody any harm............

In fact it may be essential for correct immune balance

Observations: Some depression might have roots in immune-generated inflammation

Observations: Some depression might have roots in immune-generated inflammation

The More Someone Smokes, The Smaller The Number Of Grey Cells - Science News - redOrbit

Scientists of the Charité Berlin and of PTB confirm: Smokers have a thinner cerebral cortex

The quest of tracking human mutation in the 1000 genomes project: Human mutation repertoire revealed

15 million mutations were recorded in this study of  ~800 genomes !
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Epigenetics 2010 – a new collection from the PLoS journals | The Official PLoS Blog

Epigenetics 2010 – a new collection from the PLoS journals | The Official PLoS Blog

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.

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Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.

Cannabinoid  apoptosis in immune cells

  immunosuppression.

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Rare infections mimicking multiple sclerosis

Whipple's disease, Lyme disease, Syphilis, AIDS, Brucellosis, HHV-6 infection, Hepatitis C, Mycoplasma and Creutzfeld-Jacob diseaseCat scratch disease Bartonella hensellae, Mediterranean spotted fever Riketssia connore and Leptospirosis 
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Antipsychotics associated with the development of type 2 diabetes in antipsychotic-naïve schizophrenia patients.

 type 2 diabetes 

antipsychotic

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PANDAS - Wikipedia, more about streptococcal infections

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases.

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases.

This is an old paper but very much in line with the theme that infections can have dramatic effects on behaviour.

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The importance of the development of the intestinal microbiota in infancy.

This is a diagram depicting the rise of overwe...Image via Wikipedia
The microbes in the gut can determine our subsequent susceptibility to atopy (allergies etc) and can also affect childhood obesity
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A free Collection from Nature: Super Resolution Microscopy

Collection: Super Resolution Microscopy : Nature Methods

YouTube - cellix ltd's Channel

YouTube - cellixltd's Channel So far, useful videos on thrombosis, inflammation and atherosclerosis

Learn About Mental Disorders from NARSAD

A useful site for researchers and the general public in relation to mental disorders.
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Is There a Liberal Gene? : Discovery News

This liberal gene is the dopamine receptor DRD4 gene: This has also been implicated in schizophrenia, although not in the USA . The flood of GWAS studies is likely to uncover many more strange but true  associations.
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Miami 2011 Winter Symposium: Epigenetics in Development and Disease

Epigenetics in Development and Disease
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Webinars from BD Biosciences

Webinars from BD Biosciences

HHMI News: Internal Body Temperature Turns Back Circadian Clocks

HHMI News: Internal Body Temperature Turns Back Circadian Clocks
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Sepsis Linked To Mental And Physical Decline In Older Patients

Sepsis Linked To Mental And Physical Decline In Older Patients

NIH - Health Information

A good site for all sorts of health and research information related to many diseases

Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia.

Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia.

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Metal pollution tied to Parkinson's disease | Reuters

Metal pollution tied to Parkinson's disease | Reuters (Mainly manganese )
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Non-coding small (micro) RNAs of Pseudomonas aeruginosa isolated from clinical isolates from adult patients with cystic fibrosis.

Non-coding small microRNAs of Pseudomonas aeruginosa isolated from clinical isolates from adult patients with cystic fibrosis.

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Total cholesterol and the risk of Parkinson's disease

Total cholesterol

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Epstein Barr Virus-Encoded EBNA1 Interference with MHC Class I Antigen Presentation Reveals a Close Correlation between mRNA Translation Initiation an

Antigen presentation stimulates T cells to bec...Image via Wikipedia

Epstein Barr Virus-Encoded EBNA1 Interference with MHC Class I Antigen Presentation Reveals a Close Correlation between mRNA Translation Initiation and Antigen Presentation.

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The Royal Society Digital Journal Archive, from 1665 to 2010 inclusive, will be free to view until 30 November 2010.

Journals — Royal Society Publishing

virology blog — About viruses and viral disease

virology blog — About viruses and viral disease A useful blog about viruses and microbiology

A negative regulator of MAP kinase causes depressive behavior

Access : A negative regulator of MAP kinase causes depressive behavior : Nature Medicine

New class of biomolecules triggered in response to respiratory virus infection

Non-coding RNA's that are not translated to protein, and that are larger than microRNA have an important role to play in host pathogen interactions

Childhood obesity linked to common cold virus

Childhood obesity linked to  adenovirus
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The Aging Young: Childhood Obesity At Its Worse | Medical News and Health Information

The Aging Young: Childhood Obesity At Its Worse | Medical News and Health Information
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Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway.

Protective effects of magnesium lithospermate B in atherosclerosis
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The environment and susceptibility to schizophreni... [Prog Neurobiol. 2010] - PubMed result

Environmental risk factors in schizophrenia are caralougues at this database

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.

A useful insight into the role of the APP intracellular domain

The pathogenesis of murine coronavirus infection of the central nervous system.

A useful mouse model for multiple sclerosis

Anti-cholesterol drugs could help stave off seizures, research suggests

Hot on the tail of another report showing that statins may be beneficial in prostate cancer Post
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New regulator of circadian clock identified: Dopamine study may have impact on activity and sleep rhythms in Parkinson's disease

New regulator of circadian clock identified: Dopamine study may have impact on activity and sleep rhythms in Parkinson's disease

Interesting, as circadian genes have been implicated in both Bipolar disorder and schizophrenia  Database
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Bitter Taste Receptor Found In Lungs

This may later be useful in diseases like asthma, bronchitis and emphysema, and perhaps cystic fibrosis
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Study identifies potential stroke triggers | Reuters

 This is interesting as it identifies the triggers immediately prior to a stroke - these include infection and alcohol consumption.
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Dementia in Swedish Twins: Predicting Incident Cases

Which twin would develop dementia was predicted by less favorable lipid values (higher apoB, ratio of apoB to apoA1, and total cholesterol

Cholesterol and lipoprotein related genes are listed here 
 
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Computational Neuroscience Suggests Potassium Channels More Involved in MS Than Thought | Cell Press Daily News Aggregator

Computational Neuroscience Suggests Potassium Channels More Involved in MS Than Thought | Cell Press Daily News Aggregator

Heavy Smoking Boosts Risk of Alzheimer's, Study Finds | LiveScience

GeneMANIA Fast gene function predictions

GeneMANIA

Research Links Obsessive-Compulsive Disorder To Common Childhood Illness

Strep throat is a sore throat caused  Streptococcus pyogenes, or group A streptococcus.
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Phase II Study With Ocrelizumab Shows Significant Reduction In Disease Activity For Multiple Sclerosis Patients

 Ocrelizumab is a monoclonal immunosuppressant antibody targeting B-lymphocytes
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Origin Of Immune Cells (microglia) In The Brain Discovered By Mount Sinai Researchers

Origin Of Immune Cells In The Brain Discovered By Mount Sinai Researchers

Cholesterol-lowering drug shrinks enlarged prostates in hamster model

Cholesterol-lowering drug shrinks enlarged prostates in hamster model

Observations: HIV-related memory loss shares similarity with Alzheimer's

Observations: HIV-related memory loss shares similarity with Alzheimer's

Malaria research begins to bite: Molecular switches pinpointed in control of malaria parasite's life cycle

Malaria research begins to bite: Molecular switches pinpointed in control of malaria parasite's life cycle

ARIKACE™ Demonstrates Sustained Benefit In Multiple Studies And Over Multiple Cycles Of Treatment Of Pseudomonas Lung Infections

ARIKACE™ Demonstrates Sustained Benefit In Multiple Studies And Over Multiple Cycles Of Treatment Of Pseudomonas Lung Infections

Conference: The emerging neuroscience of Autism spectrum disorders

A Brain Research Meeting

Generating and Navigating complete Proteome Maps by Mass Spectrometry: Online Webinar

Generating and Navigating complete Proteome Maps by Mass Spectrometry

Neuron: REVIEW ISSUE ON NEUROGENETICS Free access

Neuron

Invasive honeysuckle increase risk of tick-borne disease in suburbs

Deer Tick life cycle diagramImage via Wikipedia
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Discovery of taste receptors in the lungs could help people with asthma breathe easier

Discovery of taste receptors in the lungs could help people with asthma breathe easier

Few docs recognize chronic Lyme disease | Reuters

chronic Lyme disease Borrelia
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Higher education tied to rare form of diabetes | Reuters

Higher education tied to rare form of diabetes | Reuters

A Parkinson's disease environmental risk factor database

Parkinson's disease is one of the few diseases where the laboratory models faithfully match the environmental risk factors in the clinical setting. For example MPTP, rotenone or paraquat can all produce dopaminergic lesions in rodents or monkeys, as can infection with the influenza H5N1 virus in mice (see posts). This database sets out to curate the  multiple risk and protective factors that have been implicated in the human condition.

Risk factors can be added via the comments section on this post, or via a form on the website.
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A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

Molecular Psychiatry - Abstract of article: A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

Latrophilins are receptors for a spider venom, latrotoxin

Home : Functional Glycomics Gateway

Home : Functional Glycomics Gateway

Access : O2 regulates stem cells through Wnt/|[beta]|-catenin signalling : Nature Cell Biology

Access : O2 regulates stem cells through Wnt/|[beta]|-catenin signalling : Nature Cell Biology

STEP : Abstract : UCSD-Nature Molecule Pages

STEP is a key mediator regulating glutamate, dopamine and adrenaline signalling .

Visceral Adiposity Index Directly Correlated To Viral Load In Genotype 1 Chronic Hepatitis C

Visceral Adiposity Index Directly Correlated To Viral Load In Genotype 1 Chronic Hepatitis C

Genomes of lyme disease bacteria sequenced

Genomes of lyme disease bacteria sequenced

Progress in the development of new Parkinson’s drugs

Progress in the development of new Parkinson’s drugs

Immune protein linked to abnormal brain development; May provide clues to schizophrenia and autism

Immune protein linked to abnormal brain development; May provide clues to schizophrenia and autism

Peripheral induction of Alzheimer's-like brain pathology in mice

Peripheral induction of Alzheimer's-like brain pathology in mice

Evaluation of CSF Biomarkers as Predictors of Alzheimer's Disease: A Clinical Follow-Up Study of 4.7 Years

The markers were Beta-amyloid and tau
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