Adding genes and risk factors to the PolygenicPathways database

I have no doubt that many genes and risk factors have not been covered in the PolygenicPathways database and the tidal wave of GWAS data makes it difficult to keep up. If you have new genes and risk factors, could you please help by filling in the form . All I need are gene symbols and the reference or Pubmed ID.


Thanks
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Hepatitis C virus core protein induces neuroimmune activation and potentiates human immunodeficiency virus-1 neurotoxicity.

Hepatitis C virus core protein induces neuroimmune activation and potentiates human immunodeficiency virus-1 neurotoxicity.

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Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination.

Inflammation innate immunity astrocyte demyelination.

Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men.

Testosterone modifies the effect of APOE genotype ... [Neurology. 2010] - PubMed result

Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical

Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes.

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Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder

Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder

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JCV detection in multiple sclerosis patients treated with natalizumab.


JCV detection in multiple sclerosis patients treated with natalizumab.


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Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.

Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.

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Pubmed updates on Vitamin D and multiple sclerosis

Vitamin D and multiple sclerosis
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An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis.(increases MS risk)

An updated meta-analysis of risk of multiple scler... [PLoS One. 2010] - PubMed result

 ".....Our results establish firmly that a history of infectious mononucleosis significantly increases the risk of multiple sclerosis."
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ToxoDB : The Toxoplasma genome resource

ToxoDB : The Toxoplasma genome resource

Opinion: Bugs can solve food crisis - The Scientist - Magazine of the Life Sciences

Opinion: Bugs can solve food crisis - The Scientist - Magazine of the Life Sciences

Your River of Science - Research RSS Feeds Fulltext Articles - FeedNavigator

Your River of Science - Research RSS Feeds Fulltext Articles - FeedNavigator An astonishing Feed navigator from Terkko in Finland, allowing your own choice of science feeds.

Transgenic Mice with Chronic NGF Deprivation and Alzheimer's Disease-Like Pathology Display Hippocampal Region-Specific Impairments in Short- and Long-Term Plasticities -- Houeland et al. 30 (39): 13089 -- Journal of Neuroscience

Transgenic Mice with Chronic NGF Deprivation and Alzheimer's Disease-Like Pathology Display Hippocampal Region-Specific Impairments in Short- and Long-Term Plasticities -- Houeland et al. 30 (39): 13089 -- Journal of Neuroscience

Hepatitis C virus faces new weapon from Florida State scientists

Hepatitis C virus faces new weapon from Florida State scientists

Getting Off Tract: Polyglutamine Disease Involves Other Regions Of Protein

Getting Off Tract: Polyglutamine Disease Involves Other Regions Of Protein

Gut-Invading Worms Turn Enemy T Cells Into Friends

Gut-Invading Worms Turn Enemy T Cells Into Friends

Varying CRP levels in ethnic groups may affect statin eligibility, heart risk prediction

Varying CRP levels in ethnic groups may affect statin eligibility, heart risk prediction An example of how gene variants can influence the effectiveness of drugs. Statins work in some studies but not in others, particularly in Alzheimer's disease (References) , possibly in relation to such interactions


Wider statin use could be cost-effective preventive measure, study finds

Wider statin use could be cost-effective preventive measure, study finds

Poster : Regulation of microRNA biogenesis, function and degradation

Poster : Regulation of microRNA biogenesis, function and degradation

A Possible Vaccination for HIV? | Medical News and Health Information

A Possible Vaccination for HIV? | Medical News and Health Information

Key action of a gene linked to both Alzheimer's disease and type 2 diabetes identified

Key action of a gene linked to both Alzheimer's disease and type 2 diabetes identified

SORCS1

Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations

Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations

Negative data showing the herterogeneity of gene association studies

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

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CRY2 is associated with rapid cycling in bipolar disorder patients.

cryptochrome 2 is associated with rapid cycling in bipolar disorder patients.

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Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster.

Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster. This is interesting as it suggests a filament forming role for several proteins, including EIF2B, that are not normally associated with these structures
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Causes of schizophrenia: A nice review from Pediaview

Causes of schizophrenia

Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPARγ dependent signal transduction pathways.

Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPARγ dependent signal transduction pathways.

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The DISC1 and glutamate interactomes in schizophrenia and bipolar disorder

The 2007 DISC1 interactome is compared with the 2010 update for both schizophrenia and bipolar disorder related genes.

Multiple genes implicated in schizophrenia are also related to the glutamatergic synapse and this is also shown:
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Top 7 immunology papers - The Scientist - Magazine of the Life Sciences

Top 7 immunology papers - The Scientist - Magazine of the Life Sciences

Polyamine pathway contributes to the pathogenesis of Parkinson disease — PNAS

Polyamine pathway contributes to the pathogenesis of Parkinson disease — PNAS

Curry cooking ingredient could provide recipe for fight against cancer

Curry cooking ingredient could provide recipe for fight against cancer

Tracking down pathogenic yeasts

Tracking down pathogenic yeasts Candida albicans and other usually innocuous yeasts can be dangerous if the immune system is compromised
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Efficacy study of Prunus amygdalus (almond) nuts in scopolamine-induced amnesia in rats.

Efficacy study of Prunus amygdalus (almond) nuts i... [Indian J Pharmacol. 2010] - PubMed result

Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats.

Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats.

Interleukin-27: Biological Properties and Clinical application

Manifestations of Chronic Hepatitis C infection beyond the liver

Manifestations of Chronic Hepatitis C Virus Infect... [Clin Gastroenterol Hepatol. 2010] - PubMed result

DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 virus transformation in mouse fibroblasts

DJ-1, an oncogene and causative gene for familial ... [FEBS Lett. 2010] - PubMed result

Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study

Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study

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Scientists find Alzheimer's Disease reduces human brain cancer growth

Scientists find Alzheimer's Disease reduces human brain cancer growth

Cancer is inversely associated with Alzheimer's disease risk, and vice versa Roe et al 2010

The Pharmacogenomics Journal - A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

The Pharmacogenomics Journal - Abstract of article: A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
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Nature Pathway Interaction Database

Home : Pathway Interaction Database

Multiple sclerosis: Putting a dampener on inflammation - Cell Signaling Update - Signaling Gateway

Multiple sclerosis: Putting a dampener on inflammation - Cell Signaling Update - Signaling Gateway
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Alzforum: Live Discussions: Microdissection and Microarrays: Analyzing Selective Cell Vulnerability

Alzforum: Live Discussions Microdissection and Microarrays: Analyzing Selective Cell Vulnerability
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Revealing Malaria's Newest Pathway Into Human Cells

 Plasmodium falciparum uses complement receptor 1 to enter erythrocytes: This receptor also binds to Herpes simplex and the influenza virus : Powers et al, 1995
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Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir.

Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir.

Quantitative Proteomic Analyses of Influenza Virus-Infected Cultured Human Lung Cells -- Coombs et al. 84 (20): 10888 -- The Journal of Virology

Quantitative Proteomic Analyses of Influenza Virus-Infected Cultured Human Lung Cells -- Coombs et al. 84 (20): 10888 -- The Journal of Virology

Condoms can prevent transmission of herpes simplex virus 2: Study

Condoms can prevent transmission of herpes simplex virus 2: Study

Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.

Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.

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Alzforum: News: APP’s Better Half? Soluble Fragment Activates Protective Genes

Alzforum: News
Amyloid precursor protein beta-secretase
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Schizophrenia Research Forum: DISC1 2010—Development in Flies, Humans, and Mice in Between

Hakon Heimer has put together a number of interesting higlights from the DISC1 conference, which are also available from the Schizophrenia Research Forum site
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MicrobeWorld - Battle of the bacteria

MicrobeWorld - Battle of the bacteria

New View of Multiple Sclerosis | Medical News and Health Information

New View of Multiple Sclerosis | Medical News and Health Information

Protein may advance Parkinson's by preventing neurons from clearing debris

autophagy autophagosome

New target for Alzheimer's disease identified

sphingomyelinase

Genetic discovery could lead to brain treatments | Reuters

Neural stem cells SOX9

Antibodies to various mycoplasmas in patients with coronary heart disease.

Antibodies to various mycoplasmas in patients with... [Isr Med Assoc J. 2010] - PubMed result

Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain.

Immunohistological detection of Chlamydia pneumoni... [BMC Neurosci. 2010] - PubMed result
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Researchers Create First Molecule Able To Block Key Component Of Cancer Genes' On-Off Switch

Researchers Create First Molecule Able To Block Key Component Of Cancer Genes' On-Off Switch

Researchers Unlock Mystery Of Cellular/Molecular Defect That Can Lead To Human Autoimmune Disease

Researchers Unlock Mystery Of Cellular/Molecular Defect That Can Lead To Human Autoimmune Disease

euHCVdb®: The European Hepatitis C Virus Database Home Page

Hepatitis C
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NIH VideoCasting Event Summary Immune response to bacteria

NIH VideoCasting Event Summary

A neat video showing how neutrophils deal with invading bacteria
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New gene associated with increased risk of Alzheimer's disease

Ball-and-stick model of NADP+Image via Wikipedia
New gene associated with increased risk of Alzheimer's disease

MTHFD1L NCBI Gene

MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

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Chronic Lyme disease: How often is it diagnosed and treated?

Chronic Lyme disease: How often is it diagnosed and treated?
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Dangerous Blood Clot Risk Linked To Newer Antipsychotics

Dangerous Blood Clot Risk Linked To Newer Antipsychotics

Early treatment of cold sores with topical ME-609 ... [J Am Acad Dermatol. 2010] - PubMed result

Early treatment of cold sores with topical ME-609 ... [J Am Acad Dermatol. 2010] - PubMed result

Alpha- and Beta-Synucleins mRNA Expression in Lymphocytes of Schizophrenia Patients.

Alpha- and Beta-Synucleins mRNA Expression in Lymphocytes of Schizophrenia Patients

Genet Test Mol Biomarkers. 2010

Clone|Gene ID Converter

Clone|Gene ID Converter

This is useful for converting the many different gene and protein symbols and accession numbers

Cell Signal-omics 2011 - January 26 - 29, 2011, Luxembourg

Cell Signal-omics 2011 - January 26 - 29, 2011, Luxembourg

Pathway Interaction Database at Nature

Therapeutic complement inhibition: new development... [Semin Thromb Hemost. 2010] - PubMed result

Therapeutic complement inhibition: new development... [Semin Thromb Hemost. 2010] - PubMed result

Immunogenetics of systemic sclerosis. [Autoimmun Rev. 2010] - PubMed result

Immunogenetics of systemic sclerosis. [Autoimmun Rev. 2010] - PubMed result

JC virus persistence following progressive multifocal leukoencephalopathy in multiple sclerosis patients treated with natalizumab.

JC virus persistence following progressive multifocal leukoencephalopathy in multiple sclerosis patients treated with natalizumab.

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The Metatron

IPP Metatron This is unrelated but looks fascinating and more advanced than MRI.

No Hiding Place For Infecting Bacteria

 P Aeruginosa and cystic fibrosis

Immune response feeds parasite - The Scientist - Magazine of the Life Sciences

Immune response feeds parasite - The Scientist - Magazine of the Life Sciences Salmonella

A Vibrio Effector Protein Is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity -- Broberg et al. 329 (5999): 1660 -- Science

A Vibrio Effector Protein Is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity -- Broberg et al. 329 (5999): 1660 -- Science

CFS Central: XMRV Conference Recap

CFS Central: XMRV Conference Recap

Fast Food and Cheap Eats Associated With Kidney Disease | Medical News and Health Information

Fast Food and Cheap Eats Associated With Kidney Disease | Medical News and Health Information

Type D Personality & Heart Risk | Medical News and Health Information

Type D Personality & Heart Risk | Medical News and Health Information

Ligation of complement receptor 1 increases erythrocyte membrane deformability.

Ligation of complement receptor 1 increases erythr... [Blood. 2010] - PubMed result

Strains of Epstein-Barr virus infecting multiple sclerosis patients.

Strains of Epstein-Barr virus infecting multiple s... [Mult Scler. 2010] - PubMed result

For sufferers of an early-onset dementia, career choice may determine location of disease in brain

For sufferers of an early-onset dementia, career choice may determine location of disease in brain

Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.

Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.

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Immunoglobulin GM genes as functional risk and protective factors for the development of Alzheimer's disease.

Immunoglobulin GM genes

Many more immune related genes including cytokines, chemokines, Toll receptors, complement cascade components, (Complement receptor 1, C4A, C4B,  CFH and clusterin) and HLA antigens are involved in Alzheimer's disease risk, highlighting the importance of immunity and resistance to infection. 
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Raltegravir could be valid target against all Herpesviridae

Raltegravir could be valid target against all Herpesviridae
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T Cells attack neurones in multiple sclerosis model

Immunity - In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

A screening methodology based on Random Forests to improve the detection of gene–gene interactions

Random Forests

The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia

Molecular Psychiatry - The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia

Dysbindin-1, a schizophrenia-related molecule, is involved in the regulation of neuronal dendritic development

Abstract of article: Dysbindin-1, a schizophrenia-related molecule, is involved in the regulation of neuronal dendritic development

An update on epigenetic regulation in pathophysiologies of stress-induced psychiatric disorders

[An update on epigenetic regulation in pathophysio... [Nihon Shinkei Seishin Yakurigaku Zasshi. 2010] - PubMed result

Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes.

Therapeutic strategies for Alzheimer disease based on endoplasmic reticulum stress

Therapeutic strategies for Alzheimer disease based on endoplasmic reticulum stress

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Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study.

Influenza vaccination protects  against myocardial infarction (heart attacks)
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Neuroquantology

Neuroquantology An interesting take on brain function related to quantum physics:
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Gut inflammation provides a respiratory electron acceptor for Salmonella

Access : Gut inflammation provides a respiratory electron acceptor for Salmonella : Nature

RightHealth: Quality Health Information Organized for You

RightHealth: Quality Health Information Organized for You

Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells.

Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells.

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Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

Polyunsaturated liposomes are antiviral against he... [Proc Natl Acad Sci U S A. 2010] - PubMed result

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand.

Complement receptor Plasmodium falciparum

It is also a receptor for Herpes simplex and influenza viruses Powers et al, 1995 and also clears Streptococcus Pneumoniae Li et al, 2010
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Intravenous clusterin administration reduces myocardial infarct size in rats.

ORIGINAL ARTICLE: Intravenous clusterin administra... [Eur J Clin Invest. 2010] - PubMed result

Integrated Biology: What is needed to bring the Omics together?

Integrated Biology: What is needed to bring the Omics together?
A science webinar from AAAS

Groundbreaking Discovery Shows Rapid Evolution Of Bacterial Genomes Over The Course Of A Single Chronic Infection

Groundbreaking Discovery Shows Rapid Evolution Of Bacterial Genomes Over The Course Of A Single Chronic Infection

Oral Laquinimod Demonstrated Sustained Efficacy And Safety In Patients With Multiple Sclerosis

Oral Laquinimod Demonstrated Sustained Efficacy And Safety In Patients With Multiple Sclerosis

Bacteria Identified That May Lead To Inflammatory Bowel Disease In Genetically Susceptible Individuals

Bacteria Identified That May Lead To Inflammatory Bowel Disease In Genetically Susceptible Individuals

Obesity In Children Could Be Due To Viral Infection, Study

Obesity In Children Could Be Due To Viral Infection, Study

Scientists Uncover Process Enabling Toxoplasmosis Parasite To Survive Homelessness

Scientists Uncover Process Enabling Toxoplasmosis Parasite To Survive Homelessness

Top 7 in cell biology - The Scientist - Magazine of the Life Sciences

Top 7 in cell biology - The Scientist - Magazine of the Life Sciences

Microbial Identification_Biolog

Biolog Microbial Identification Systems offers a fast and easy way to identify more than 2200 species of bacteria, yeast and filamentous fungi. A single panel provides definitive results in as little as 4 hours. A variety of systems are available to meet throughput and budget requirements.

The Great Beyond: A new tool for predicting type II diabetes

The Great Beyond: A new tool for predicting type II diabetes

Relation between Epstein-Barr virus and multiple sclerosis: analytic study of scientific production.

"This meta-analysis detected an association between infection by the Epstein-Barr virus  and MS through the investigation of antibodies, mainly anti-EBNA-1, anti-complex EBNA and anti-VCA IgG".
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Relation between Epstein-Barr virus and multiple sclerosis: analytic study of scientific production.

Relation between Epstein-Barr virus and multiple s... [Eur J Clin Microbiol Infect Dis. 2010] - PubMed result

Relation between Epstein-Barr virus and multiple sclerosis: analytic study of scientific production.

Relation between Epstein-Barr virus and multiple s... [Eur J Clin Microbiol Infect Dis. 2010] - PubMed result

Severity of experimental autoimmune encephalomyelitis is unexpectedly reduced in mice born to vitamin D-deficient mothers.

Severity of experimental autoimmune encephalomyelitis is unexpectedly reduced in mice born to vitamin D-deficient mothers.

......not much sunlight in the womb !

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Association of the clusterin gene polymorphisms with type 2 diabetes mellitus.

Very interesting because of the asociation between diabetes and Alzheimer's disease

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Interactions between age, stress and insulin on cognition: implications for Alzheimer's disease.

Interactions between age, stress and insulin on co... [Neuropsychopharmacology. 2010] - PubMed result

Identification of High Risk DISC1 Protein Structural Variants in Patients with Bipolar Spectrum Disorder.

Identification of High Risk DISC1 Protein Structural Variants in Patients with Bipolar Spectrum Disorder.

Reversal of memory deficits by Coriandrum sativum leaves in mice.

Coriandrum sativum (habit). Location: Maui, Ku...Image via Wikipedia
Reversal of memory deficits by Coriandrum sativum
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Virus Pathogen Database and Analysis Resource (ViPR) - Genome database with visualization and analysis tools

Virus Pathogen Database and Analysis Resource (ViPR) - Genome database with visualization and analysis tools

Journal Of Psychopharmacology Publishes Anti-Amnesic And Neuroprotective Data Against Amyloid Toxicity For First Of A New Class In Alzheimer's Disease

Journal Of Psychopharmacology Publishes Anti-Amnesic And Neuroprotective Data Against Amyloid Toxicity For First Of A New Class In Alzheimer's Disease

Adolescents with fibromyalgia who are physically active report lower levels of pain and disability

Adolescents with fibromyalgia who are physically active report lower levels of pain and disability

Cholesterol drug may have role in treating prostate cancer

Cholesterol drug may have role in treating prostate cancer

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition — PNAS

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition — PNAS "..................the spatial distribution of aerobic glycolysis in normal young adults correlates spatially with Aβ deposition in individuals with DAT and cognitively normal participants with elevated Aβ, suggesting a possible link between regional aerobic glycolysis in young adulthood and later development of Alzheimer pathology". CMR glu is reduced prior to discernible symptoms in Alzheimer's disease (Cutler 1986) and correlates with deficits in AD patients Rapoport 1986
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Receptor physiology: It's the NMDA receptor, but not as we know it : Nature Reviews Neuroscience

"Unlike most NMDA (N-methyl-D-aspartate) receptor (NMDAR) subunit combinations, which require glycine and glutamate for activation, NMDARs that contain both NR1 and NR3 subunits (NR1/NR3 receptors) are activated by glycine alone. This property and other unusual properties of this receptor subtype were discovered following experiments in recombinant expression systems but had been difficult to demonstrate in vivo"
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Autism Blog - Why are autistic people mainly male? « Left Brain/Right Brain

Autism Blog - Why are autistic people mainly male? « Left Brain/Right Brain
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Popular Asian spice can cure Alzheimer's disease

Popular Asian spice can cure Alzheimer's disease

The promise and reality of pharmacogenetics in psychiatry.

The promise and reality of pharmacogenetics in psychiatry.

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Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia.

Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia.

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Chronic Stress May Cause Long-Lasting Epigenetic Changes

Epigenetics corticosterone

Chlamydia pneumoniae infection as a risk factor for accelerated atherosclerosis in hemodialysis patients.

Age-standardised disability-adjusted life year...Image via Wikipedia

Chlamydia pneumoniae infection as a risk factor for accelerated atherosclerosis in hemodialysis patients.

Chlamydia map

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Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia.

Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia.

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