The Apo E Gene Diet: A Breakthrough in Changing Cholesterol, Weight, Heart and Alzheimer's Using the Body's Own Genes
Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment.
Cholesterol genes in Alzheimer's
The Apo E Gene Diet: A Breakthrough in Changing Cholesterol, Weight, Heart and Alzheimer's Using the Body's Own Genes
The Apo E Gene Diet: A Breakthrough in Changing Cholesterol, Weight, Heart and Alzheimer's Using the Body's Own Genes
Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses.
A number of synapse related genes have been implicated in both bipolar disorder and schizophrenia in pre-GWAS genetic association studies. These are listed at the PolygenicPathways database and a glutamatergic interactome is also available. Interactome wiki
Phospholipid Transfer Protein in Human Plasma Associates with Proteins Linked to Immunity and Inflammation.
The transfer protein associates with clusterin and other lipoproteins forming an interesting network
APP, APOE, Complement receptor 1, Clusterin and PICALM and their involvement in the Herpes simplex life-cycle
The major Alzheimer’s disease susceptibility genes (APOE, Clusterin, Complement receptor 1 (CR1) and phosphatidylinositol binding clathrin assembly protein, PICALM) can be implicated directly (APOE, CR1) or indirectly (clusterin and PICALM) in the Herpes simplex life cycle. The virus binds to proteoliposomes containing APOE or APOA1 and also to CR1, and both clusterin and PICALM are related to a mannose 6-phosphate receptor used by the virus for cellular entry and intracellular transport. PICALM also binds to a nuclear exportin used by the virus for nuclear egress. Clusterin and complement receptor 1 are both related to the complement pathways and play a general role in pathogen defence. In addition, the amyloid precursor protein APP is involved in Herpes viral transport and gamma-secretase cleaves a number of receptors used by the virus for cellular entry. APOE , APOA1 and clusterin, or alpha 2-macroglobulin, insulysin and caspase 3, which also bind to the virus, are involved in beta-amyloid clearance or degradation, as are the viral binding complement components, C3 and CR1. There are multiple ways in which the products of key susceptibility genes might be able to modify the viral life cycle and in turn the virus interacts with key proteins involved in APP and beta-amyloid processing. These interactions support a role for the Herpes simplex virus in Alzheimer’s disease pathology and suggest that antiviral agents or vaccination might be considered as viable therapeutic strategies in Alzheimer’s disease.
Neuroscience Letters 2010
Neuroscience Letters 2010
Common variants conferring risk of schizophrenia: A pathway analysis of GWAS data.
Prior to GWAS studies, a glutamatergic network had already been noted, based on old-fashioned genetic association data Carter, 2006 . A glutamatergic or DISC1 interactome in Bipolar disorder and schizophrenia is also available.
Protein/Protein Interaction Prediction: Interactome, Protein/Protein Interaction, Two-Hybrid Screening, Mass Spectrometry, Protein Microarray
Pregnancy infections in mothers of chronic schizophrenic patients. The significance of differential nosology
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The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia--the risk factor or an indication of a contact with cat?
Obesity and Body Shape Linked to Poorer Brain Function in Women
This is in line with the reports that "bad fats" (saturated) increase the risk for dementia and that "good fats" the polyunsaturated kind found in the Mediterranean diet may be beneficial See Alzheimer's disease risk factors for references
Risk Factors for Alzheimer's Disease (A collaborative Re-Analysis of Case Control Studies)
The Mediterranean Diet
Risk Factors for Alzheimer's Disease (A collaborative Re-Analysis of Case Control Studies)
The Mediterranean Diet
A potential cure for Alzheimer's disease ?
Beta-amyloid and the mutant APP proteins contain short contiguous amino acid stretches exactly matching those in multiple viruse, phages and bacteria, many of which have been implicated in Alzheimer's disease. These viral matches are often immunogenic and could also target the human proteins, killing the neurones in which they reside by autoimmune activation inflammatory mechanisms and complement-related lysis. This suggests that immunosuppressants could delay the onset and halt the progression of both late-onset and familial Alzheimer's disease.
A cure for Huntington's disease ?
The mutant protein in Huntington's disease and other polyglutamine disorders (spinocerebellar ataxias, Dentatorubropallidoluysian atrophy, Kennedy disease) aligns with immunogenic proteins from very common phages and viruses. Antibodies to these phages and viruses could also target the mutant human protein, killing the cells where it is expressed by autoimmune activation.This suggests that immunosuppressants might delay the onset and prevent the progression of these diseases.
Download .pdf
Download .pdf
Of Bugs & Brains: Caltech Researchers Discover that Gut Bacteria Affect Multiple Sclerosis - Caltech Media Relation... http://ping.fm/ognSN
A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis
Rare infections mimicking MS. [Clin Neurol Neurosurg. 2010]
Integrated cellular pathology - Systems biology of human disease - January 26 - 29, 2011, Luxembourg
The geographical distribution of positive and negative gene association data in Alzheimer's disease and schizophren... http://ping.fm/pk3lq
The geographical distribution of positive and negative gene association data in Alzheimer's disease and schizophrenia
If there is one factor common to genetic association studies it is their heterogeneity Bertram and Tanzi 2004 Shi et al, 2008 Dozen of confusing positive and negative studies blur the picture and suggest that many are related to artefact or insufficient statistical power. However, while at a global level these results are contentious, at a local level they can be quite homogenous, tending to cluster in positive or negative association hot and coldspots around the world.These examples are taken from data from the Alzgene and Szgene databases and are posted to illustrate this phenomenon.
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