Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration.

Microarray gene expression analysis of cells treated with paraquat, a mitochondrial complex 1 inhibitor showed dysregulation of genes involved in neuritogenesis, axon growth and guidance, and synaptogenesis.
Paraquat kills dopaminergic neurones via inhibition of mitochondrial complex 1 of the respiratory chain :

This is also relevant to the recent report citing pesticide use as a risk factor in Alzheimer's disease

Mitochondria posts
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