DreamHost promo codes PolygenicBlog: Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration.

Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration.

Microarray gene expression analysis of cells treated with paraquat, a mitochondrial complex 1 inhibitor showed dysregulation of genes involved in neuritogenesis, axon growth and guidance, and synaptogenesis.
Paraquat kills dopaminergic neurones via inhibition of mitochondrial complex 1 of the respiratory chain :

This is also relevant to the recent report citing pesticide use as a risk factor in Alzheimer's disease

Mitochondria posts
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